A new tumor biomarker, serum protein peak at 3,144 m/z, in patients with node-positive breast cáncer

ABSTRACT

Purpose: To explore the association between the 3,144 m/ z protein peak and the clinicopathological features and prognosis in breast cancer. Methods: Using SELDI–TOF MS, we analyzed serum protein peak at 3,144 m/z in 283 patients with node-positive breast cancer, its relationship with clinicopathological features and their prognosis evaluating value of survival. Results 3,144 m/z positive rate was higher in elderly patients (42.8 % in C50-year-old vs. 31.2 % in (, P = 0.04). However, no correlation was observed between 3,144 m/z and other clinicopathological features (body mass index, menstrual status, family history, TNM, molecular subtypes, vascular invasion, neural invasion, p53 and CA15-3). However, the positive rate of 3,144 m/z was higher than that of CA15-3 (35.5 vs. 11.4 %, McNemar v2 test, p