Impaired in-vitro responses to IL-12 and IFN-γ in Iranian patients with Mendelian susceptibility to mycobacterial disease
Allergol. immunopatol
; 43(5): 456-460, sept.-oct. 2015. tab, graf
Artigo
em Inglês
| IBECS
| ID: ibc-141105
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
INTRODUCTION:
Diagnosis of specific molecular defects of Mendelian susceptibility to mycobacterial diseases (MSMD) patients is important with respect to their clinical outcomes and their response to therapy. The aim of this study was to perform functional tests on blood samples of a group of patients who were suspected of having MSMD.METHODS:
This study was performed on 11 cases who had mycobacterial infections and suspected MSMD. Whole blood cell culture was performed in presence of different stimulators. The supernatants were assayed for IFN-γ, IL-12p40 by ELISA method.RESULTS:
All patients presented with complications of BCG vaccine in the form of localised lymphadenitis or disseminated BCG infection and chronic mycobacterial osteomyelitis. Infections with Salmonellaspecies occurred in two patients. In-vitro studies showed that 10 cases had impaired response to IL-12. However, the baseline levels of IL-12p40 were normal, while one of our patients may have a potential IFN-γ signalling defect or an IL-12p40 defect.CONCLUSIONS:
Early detection of MSMD and commencing of appropriate combination therapy could prevent severe or even fatal complications of uncontrolled mycobacterial infectionsRESUMEN
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Coleções:
Bases de dados nacionais
/
Espanha
Contexto em Saúde:
Doenças Negligenciadas
Problema de saúde:
Doenças Negligenciadas
/
Tuberculose
/
Zoonoses
Base de dados:
IBECS
Assunto principal:
Vacina BCG
/
Interferon gama
/
Interleucina-12
/
Subunidade p40 da Interleucina-12
/
Subunidade beta 1 de Receptor de Interleucina-12
/
Monitoramento Epidemiológico
/
Infecções por Mycobacterium
Tipo de estudo:
Estudo de rastreamento
Limite:
Criança
/
Feminino
/
Humanos
/
Lactente
/
Masculino
/
Recém-Nascido
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Allergol. immunopatol
Ano de publicação:
2015
Tipo de documento:
Artigo
Instituição/País de afiliação:
Tehran University of Medical Sciences/Iran