Repair of bone defect by nano-modified white mineral trioxide aggregates in rabbit: A histopathological study
Med. oral patol. oral cir. bucal (Internet)
; 20(5): e525-e531, sept. 2015. ilus, tab
Article
em En
| IBECS
| ID: ibc-142979
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
BACKGROUND: Many researchers have tried to enhance materials functions in different aspects of science using nano-modification method, and in many cases the results have been encouraging. To evaluate the histopathological responses of the micro-/nano-size cement-type biomaterials derived from calcium silicate-based composition with addition of nano tricalcium aluminate (3CaO.Al2 O3 ) on bone healing response. MATERIAL AND METHODS: Ninety mature male rabbits were anesthetized and a bone defect was created in the right mandible. The rabbits were divided into three groups, which were in turn subdivided into five subgroups with six animals each based on the defect filled by: white mineral trioxide aggregate (WMTA), Nano-WMTA, WMTA without 3CaO.Al2 O3 , Nano-WMTA with 2% Nano-3CaO.Al2 O3 , and empty as control. Twenty, forty and sixty days postoperatively the animals were sacrificed and the right mandibles were removed for histopathological evaluations. Kruskal-Wallis test with post-hoc comparisons based on the LSMeans procedure was used for data analysis. RESULTS: All the experimental materials provoked a moderate to severe inflammatory reaction, which significantly differed from the control group (p< 0.05). Statistical analysis of bone formation and bone regeneration data showed significant differences between groups at 40- and 60- day intervals in all groups. Absence of 3CaO.Al2 O3 leads to more inflammation and foreign body reaction than other groups in all time intervals. CONCLUSIONS: Both powder nano-modification and addition of 2% Nano-3CaO.Al2 O3 to calcium silicate-based cement enhanced the favorable tissue response and osteogenesis properties of WMTA based materials
Texto completo:
1
Coleções:
06-national
/
ES
Base de dados:
IBECS
Assunto principal:
Regeneração Óssea
/
Nanoestruturas
/
Óxido de Cálcio
Limite:
Animals
Idioma:
En
Revista:
Med. oral patol. oral cir. bucal (Internet)
Ano de publicação:
2015
Tipo de documento:
Article