Startle modification and P50 gating in schizophrenia patients and controls: Russian population
Span. j. psychol
; 19: e8.1-e8.11, 2016. tab
Artigo
em Inglês
| IBECS
| ID: ibc-149694
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
Prepulse modification of the acoustic startle response (ASR) and P50 gating are potential neurophysiological endophenotypes of schizophrenia and may be used in the construction of valid clinical biomarkers. Such approach requires a large amount of data obtained in the representative samples from different gender, socio-typological and ethnic groups, replicating studies using the similar protocols and meta-analyses. This is a replication study of ASR and the first study of P50 suppression in Russian patients with schizophrenia (n = 28) and healthy controls (n = 25). ASR and P50 were estimated according to standard protocols. Patients exhibited increased baseline ASR latency (d = 0.35, p = .026) and reduced prepulse inhibition (PPI) at 60 ms interval (d = 0.39, p = .003) and 120 ms interval (d = 0.37, p = .005) relative to controls. In the P50 test patients displayed greater S2 response amplitude (d = 0.24, p = .036) and deficit of P50 suppression (d = 0.43, p = .001). No correlations of PPI and P50 suppression were found in both groups. Only in controls prepulse ASR facilitation (at 2500 ms interval) positively correlated with P50 suppression (r = -.514, p = .013). In patients PPI displayed significant correlations with Difficulty in abstract thinking (N5 r = -.49, p = .005) and Hallucination (P3 r = .40, p = .036) PANSS scales. Logistic regression showed that the combination of PPI and P50 suppression could serve as a diagnostic predictor. Obtained results demonstrated that both PPI and P50 could be regarded as potential schizophrenia biomarkers in Russian population (AU)
RESUMEN
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Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Esquizofrenia
/
Reflexo de Sobressalto
/
Potenciais Evocados Auditivos
/
Inibição Pré-Pulso
Tipo de estudo:
Guia de prática clínica
/
Estudo prognóstico
Limite:
Adulto
/
Humanos
/
Masculino
País/Região como assunto:
Ásia
/
Europa
Idioma:
Inglês
Revista:
Span. j. psychol
Ano de publicação:
2016
Tipo de documento:
Artigo
Instituição/País de afiliação:
Johns Hopkins Universit/USA
/
Serbsky National Research Centre for Social and Forensic Psychiatry/Russia