Glycolytic activity in breast cancer using 18F-FDG PET/CT as prognostic predictor: A molecular phenotype approach / Actividad glicolítica en el cancer de mama mediante 18F-FDG PET/TC como predictor pronóstico: aproximación del fenotipo molecular
Rev. esp. med. nucl. imagen mol. (Ed. impr.)
; 35(3): 152-158, mayo-jun. 2016. tab, graf, ilus
Article
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| IBECS
| ID: ibc-152352
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
Aim. To explore the relationship between basal 18F-FDG uptake in breast tumors and survival in patients with breast cancer (BC) using a molecular phenotype approach. Material and Methods. This prospective and multicentre study included 193 women diagnosed with BC. All patients underwent an 18F-FDG PET/CT prior to treatment. Maximum standardized uptake value (SUVmax) in tumor (T), lymph nodes (N), and the N/T index was obtained in all the cases. Metabolic stage was established. As regards biological prognostic parameters, tumors were classified into molecular sub-types and risk categories. Overall survival (OS) and disease free survival (DFS) were obtained. An analysis was performed on the relationship between semi-quantitative metabolic parameters with molecular phenotypes and risk categories. The effect of molecular sub-type and risk categories in prognosis was analyzed using Kaplan-Meier and univariate and multivariate tests. Results. Statistical differences were found in both SUVT and SUVN, according to the molecular sub-types and risk classifications, with higher semi-quantitative values in more biologically aggressive tumors. No statistical differences were observed with respect to the N/T index. KaplanMeier analysis revealed that risk categories were significantly related to DFS and OS. In the multivariate analysis, metabolic stage and risk phenotype showed a significant association with DFS. Conclusion. High-risk phenotype category showed a worst prognosis with respect to the other categories with higher SUVmax in primary tumor and lymph nodes (AU)
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Coleções:
06-national
/
ES
Base de dados:
IBECS
Assunto principal:
Prognóstico
/
Neoplasias da Mama
/
Fatores Biológicos
/
Intervalo Livre de Doença
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Fluordesoxiglucose F18
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Sobrevivência
/
Linfonodos
Tipo de estudo:
Clinical_trials
/
Observational_studies
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Prognostic_studies
/
Risk_factors_studies
Limite:
Female
/
Humans
Idioma:
En
Revista:
Rev. esp. med. nucl. imagen mol. (Ed. impr.)
Ano de publicação:
2016
Tipo de documento:
Article