Positive effect of platelet rich fibrin on osseointegration
Med. oral patol. oral cir. bucal (Internet)
; 21(5): e601-e607, sept. 2016. ilus
Artigo
em Inglês
| IBECS
| ID: ibc-155772
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
BACKGROUND:
Leukocyte-platelet rich fibrin (L-PRF) is a second generation platelet concentrate clinically used to accelerate tissue healing and bone regeneration. Achieving reduced implant osseointegration time could provide immediate or early loading of implants. The aim of this study was to evaluate the L-PRF-induced osseointegration and bone-implant contact (BIC) in an experimental animal model. MATERIAL ANDMETHODS:
Twelve 4-month-old New Zealand white rabbits were used. Following general anesthesia, 3-5 mL of blood was obtained from the central artery in rabbit ear and L-PRF was prepared. Two implant cavities (5 mm long and 3 mm in diameter) were created in each tibia with a total of four cavities in each animal. Two of these cavities were selected and covered with PRF (test group). The remaining L-PRF was used to soak the implants placed into the L-PRF covered sockets. Other cavities were left as controls. In total, 48 implants were placed. Animals were sacrificed after two, three, or four weeks. Histological samples were obtained and periimplant tissues were histomorphometrically evaluated for bone-to-implant contact and new bone formation.RESULTS:
Histomorphometric analyses of the defects revealed that the L-PRF was detectable up to the second week. Application of L-PRF increased the rate and amount of new bone formation in the experimental group compared to the control group. Bone-to-implant contact was enhanced when the surface was prewetted with LPRF (p < 0.01).CONCLUSIONS:
The results of this study demonstrated that L-PRF application may increases amount and rate of new bone formation during the early healing period and provides a faster osseointegration around implants
Texto completo:
Disponível
Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Adesivo Tecidual de Fibrina
/
Osseointegração
/
Implantação Dentária Endóssea
/
Plasma Rico em Plaquetas
Tipo de estudo:
Estudo prognóstico
Limite:
Humanos
Idioma:
Inglês
Revista:
Med. oral patol. oral cir. bucal (Internet)
Ano de publicação:
2016
Tipo de documento:
Artigo
Instituição/País de afiliação:
Baskent University/Turkey
/
Necmettin Erbakan University/Turkey
/
The Forsyth Institute/United States