Lubricin in synovial fluid of mild and severe temporomandibular joint internal derangements
Med. oral patol. oral cir. bucal (Internet)
; 21(6): e793-e799, nov. 2016. ilus, tab, graf
Article
em En
| IBECS
| ID: ibc-157761
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
BACKGROUND: To understand the molecular basis of temporomandibular joint (TMJ) pathologies, we aimed to investigate the lubricin levels in the TMJ synovial fluid (SF) of patients with mild to severe internal derangements (IDs). MATERIAL AND METHODS: A total, 34 joints were the study group. Only patients, with a Wilkes stage of III, IV and V were included, in this sample. Control group consisted of SF from eight joints, from patients undergoing to orthognatic surgery. Concentrations of lubricin in the SF from both samples were measured using ELISA system. RESULTS: The mean lubricin concentration was 7.029 ± 0.21 mig/mL in stage III patients; 5.64 ± 0.10 mig/mL in stage IV patients, and 4.78 ± 0.11 mig/mL in stage V patients. The lubricin levels from stage IV and stage V patients differed significantly (P ≤ 0.001) from those of control subjects. Lubricin levels were inversely correlated with age and to VAS score. CONCLUSIONS: The results of this cross-sectional study highlight the relationship between disease severity and the levels of lubricin in TMJ SF. Our findings suggest that novel biotherapeutic approaches, including the administration of recombinant lubricin in the joint cavity, for the treatment of TMJ diseases can be developed
Texto completo:
1
Coleções:
06-national
/
ES
Base de dados:
IBECS
Assunto principal:
Líquido Sinovial
/
Glicoproteínas
/
Transtornos da Articulação Temporomandibular
Tipo de estudo:
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
Med. oral patol. oral cir. bucal (Internet)
Ano de publicação:
2016
Tipo de documento:
Article