Serum vitamin D levels decrease in children with acute urticarial
Allergol. immunopatol
; 44(6): 512-516, nov.-dic. 2016. graf, tab
Artigo
em Inglês
| IBECS
| ID: ibc-157871
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
BACKGROUND:
Acute urticaria is an immune-inflammatory disease, characterised by acute immune activation. There has been increasing evidence showing that vitamin D deficiency is associated with increased incidence and severity of immune-inflammatory disorders.OBJECTIVE:
The aim of this study was to evaluate serum vitamin D levels in acute urticaria.METHODS:
We enrolled 30 children with acute urticaria and 30 control subjects. Concentrations of 25-hydroxyvitamin D [25(OH)D], a biomarker of vitamin D status, were measured in serum of acute urticaria patients and compared with the control group.RESULTS:
There were no significant differences in baseline variables (age, gender, weight) between the groups. Vitamin D deficiency (<20ng/ml) was significantly higher in patients with acute urticaria than in control patients. Serum 25(OH)D levels were significantly lower in the study group compared to those in the control group (13.1±4.3 vs 28.2±7.4ng/mL, p < 0.05). Moreover, we found negative correlation between mean duration of acute urticaria and serum vitamin D levels (p < 0.01).CONCLUSION:
This study revealed a significant association of lower serum 25(OH)D concentrations with acute urticaria and an inverse relationship with disease duration. These findings may open up the possibility of the clinical use of vitamin D as a contributing factor in the pathogenesis of acute urticaria and a predictive marker for disease activity in acute urticaria. A potential role of vitamin D in pathogenesis and additive therapy in acute urticaria needs to be examinedRESUMEN
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Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Urticária
/
Vitamina D
/
Deficiência de Vitamina D
/
Hidroxicolecalciferóis
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
Limite:
Criança
/
Humanos
Idioma:
Inglês
Revista:
Allergol. immunopatol
Ano de publicação:
2016
Tipo de documento:
Artigo
Instituição/País de afiliação:
Baskent University/Turkey