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Neutrophil to lymphocyte ratio associated with prognosis of lung cancer
Bar-Ad, V; Palmer, J; Li, L; Lai, Y; Lu, B; Myers, RE; Ye, Z; Axelrod, R; Johnson, JM; Werner-Wasik, M; Cowan, SW; Evans, NR; Hehn, BT; Solomides, CC; Wang, C.
Afiliação
  • Bar-Ad, V; Thomas Jefferson University. Sidney Kimmel Medical College. Department of Radiation Oncology. Philadelphia. USA
  • Palmer, J; Thomas Jefferson University. Sidney Kimmel Medical College. Department of Radiation Oncology. Philadelphia. USA
  • Li, L; Thomas Jefferson University. Department of Medical Oncology. Philadelphia. USA
  • Lai, Y; Thomas Jefferson University. Department of Medical Oncology. Philadelphia. USA
  • Lu, B; Thomas Jefferson University. Sidney Kimmel Medical College. Department of Radiation Oncology. Philadelphia. USA
  • Myers, RE; Thomas Jefferson University. Department of Medical Oncology. Philadelphia. USA
  • Ye, Z; Thomas Jefferson University. Department of Medical Oncology. Philadelphia. USA
  • Axelrod, R; Thomas Jefferson University. Sidney Kimmel Medical College. Department of Medical Oncology. Philadelphia. USA
  • Johnson, JM; Thomas Jefferson University. Sidney Kimmel Medical College. Department of Medical Oncology. Philadelphia. USA
  • Werner-Wasik, M; Thomas Jefferson University. Sidney Kimmel Medical College. Department of Radiation Oncology. Philadelphia. USA
  • Cowan, SW; Thomas Jefferson University. Sidney Kimmel Medical College. Department of Thoracic Surgery. Philadelphia. USA
  • Evans, NR; Thomas Jefferson University. Sidney Kimmel Medical College. Department of Thoracic Surgery. Philadelphia. USA
  • Hehn, BT; Thomas Jefferson University. Sidney Kimmel Medical College. Department of Pulmonology. Philadelphia. USA
  • Solomides, CC; Thomas Jefferson University. Sidney Kimmel Medical College. Department of Pathology. Philadelphia. USA
  • Wang, C; Thomas Jefferson University. Department of Medical Oncology. Philadelphia. USA
Clin. transl. oncol. (Print) ; 19(6): 711-717, jun. 2017. tab, graf
Article em En | IBECS | ID: ibc-162828
Biblioteca responsável: ES1.1
Localização: BNCS
ABSTRACT
Purpose. Many studies recently focus on complicated and expensive genomic tests, but the prognostic values of biochemical markers which are easily obtained in clinics are largely overlooked and without further exploration. This study assesses the association of neutrophil-lymphocyte-ratio (NLR) with prognosis of lung cancer patients. Methods. In 1032 patients with histologically confirmed lung cancer, the association of pretreatment NLR values with overall survival (OS) was evaluated using a Cox proportional hazards model and the temporal relationship of longitudinal NLR was assessed using a mixed effects model. Results. Compared to the patients with a low pretreatment NLR value, those with elevated NLR exhibited a statistically significant worse OS with a hazard ratio (HR) of 1.50 (P < 0.0001) after adjusting for age, gender, race, smoking status, drinking status, tumor stage, tumor grade, histology, and treatments. A significant trend of increasing HRs along with increasing NLR values was observed. The increased risk of death conferred by pretreatment NLR values reached a peak level around 2 years after diagnosis. Moreover, in longitudinal analysis, we observed a trend of dramatically increased NLR values in patients who died during follow-up, but stable NLR values in those who were still alive, with a significant interaction of death-alive status with follow-up time (P < 0.0001). Conclusions. Elevated NLR is a potential biomarker to identify lung cancer patients with poor prognosis and should be validated in a future clinical trial (AU)
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Coleções: 06-national / ES Base de dados: IBECS Assunto principal: Linfócitos / Biomarcadores Tumorais / Neoplasias Pulmonares / Neutrófilos Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Clin. transl. oncol. (Print) Ano de publicação: 2017 Tipo de documento: Article
Buscar no Google
Coleções: 06-national / ES Base de dados: IBECS Assunto principal: Linfócitos / Biomarcadores Tumorais / Neoplasias Pulmonares / Neutrófilos Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Clin. transl. oncol. (Print) Ano de publicação: 2017 Tipo de documento: Article