The role and clinical implications of the endosteal niche and osteoblasts in regulating leukemia
Clin. transl. oncol. (Print)
; 19(9): 1059-1066, sept. 2017. ilus, tab
Artigo
em Inglês
| IBECS
| ID: ibc-165206
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
Osteoblasts are one among the critical components of the endosteal bone marrow (BM) niche. In addition to hematopoietic stem cell fate, their role in leukemogenesis as well as metastasis of a variety of cancers has been demonstrated in various studies. In this regard, endosteal niche can have a dual role as an initiator and protective role against leukemia. Knowledge of growth factors, chemokines and cytokines secreted by osteoblasts as well as their interaction with signaling pathways inform our understanding of the development, prognosis, recurrence and treatment of malignant BM diseases. Clinical progress in targeting the endosteal niche is also discussed (AU)
RESUMEN
No disponible
Buscar no Google
Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Osteoblastos
/
Medula Óssea
/
Leucemia
/
Nicho de Células-Tronco
/
Metástase Neoplásica
Tipo de estudo:
Estudo diagnóstico
/
Estudo prognóstico
Limite:
Humanos
Idioma:
Inglês
Revista:
Clin. transl. oncol. (Print)
Ano de publicação:
2017
Tipo de documento:
Artigo
Instituição/País de afiliação:
Ahvaz Jundishapur University of Medical Sciences/Iran
/
University of Florida/USA