A critical review on serine protease: Key immune manipulator and pathology mediator
Allergol. immunopatol
; 45(6): 579-591, nov.-dic. 2017. graf, ilus
Artigo
em Inglês
| IBECS
| ID: ibc-168467
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
Proteolytic activity is fundamental to survival, so it is not surprising that all living organisms have proteases, especially seine protease. This enzyme in its numerous isoforms and homologues, constitutes the quintessential offence and defence factors, in the form of surface proteins, secreted molecules, gut digestive enzymes, venom in specialised glands or plant latex, among other manifestations. Occurring as trypsin, chymotrypsin, elastase, collagenase, thrombin, subtilisin etc., it mediates a diverse array of functions, including pathological roles as inflammatory, coagulatory to haemorrhagic. This review emphasizes that despite the superficial differences in mechanisms, most health issues, be they infectious, allergic, metabolic, or neural have a common conduit. This enzyme, in its various glycosylated forms leads to signal misinterpretations, wreaking havoc. However, organisms are endowed with serine protease inhibitors which might restrain this ubiquitous yet deleterious enzyme. Hence, serine proteases-driven pathogenesis and antagonising role of inhibitors is the focal point of this critical review (AU)
RESUMEN
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Coleções:
Bases de dados nacionais
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Espanha
Base de dados:
IBECS
Assunto principal:
Serina Proteases
/
Hipersensibilidade
/
Inflamação
Limite:
Humanos
Idioma:
Inglês
Revista:
Allergol. immunopatol
Ano de publicação:
2017
Tipo de documento:
Artigo
Instituição/País de afiliação:
San Diego State University/USA