T6SS intraspecific competition orchestrates Vibrio cholerae genotypic diversity
Int. microbiol
; 20(3): 130-137, sept. 2017. ilus
Artigo
em Inglês
| IBECS
| ID: ibc-171331
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
Vibrio cholerae is a diverse species that inhabits a wide range of environments from copepods in brackish water to the intestines of humans. In order to remain competitive, V. cholerae uses the versatile type-VI secretion system (T6SS) to secrete anti-prokaryotic and anti-eukaryotic effectors. In addition to competing with other bacterial species, V. cholerae strains also compete with one another. Some strains are able to coexist, and are referred to as belonging to the same compatibility group. Challenged by diverse competitors in various environments, different V. choleare strains secrete different combination of effectors - presumably to best suit their niche. Interestingly, all pandemic V. cholerae strains encode the same three effectors. In addition to the diversity displayed in the encoded effectors, the regulation of V. cholerae also differs between strains. Two main layers of regulation appear to exist. One strategy connects T6SS activity with behavior that is suited to fighting eukaryotic cells, while the other is linked with natural competence - the ability of the bacterium to acquire and incorporate extracellular DNA. This relationship between bacterial killing and natural competence is potentially a source of diversification for V. cholerae as it has been shown to incorporate the DNA of cells recently killed through T6SS activity. It is through this process that we hypothesize the transfer of virulence factors, including T6SS effector modules, to happen. Switching of T6SS effectors has the potential to change the range of competitors V. cholerae can kill and to newly define which strains V. cholerae can co-exist with, two important parameters for survival in diverse environments (AU)
RESUMEN
No disponible
Texto completo:
Disponível
Coleções:
Bases de dados nacionais
/
Espanha
Contexto em Saúde:
Doenças Negligenciadas
Problema de saúde:
Cólera
/
Doenças Negligenciadas
Base de dados:
IBECS
Assunto principal:
Vibrio cholerae
/
Fatores de Iniciação em Procariotos
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Eucariotos
/
Sistemas de Secreção Bacterianos
/
Sistemas de Secreção Tipo VI
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Int. microbiol
Ano de publicação:
2017
Tipo de documento:
Artigo
Instituição/País de afiliação:
University of Alberta/Canada
/
University of Colorado School of Medicine/United States
/
University of Oxford/United Kingdom
/
University of Texas Rio Grande Valley/United States