Divergent functional roles of D-amino acids secreted by Vibrio cholera
Int. microbiol
; 20(3): 149-150, sept. 2017.
Article
em En
| IBECS
| ID: ibc-171333
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
The L-forms of amino acids are used in all kingdoms of life to synthesize proteins. However, the bacterium Vibrio cholerae, the causative agent of cholera, produces D-amino acids which are released to the environment at millimolar concentrations. We baptized these D-amino acids as non-canonical D-amino acids (NCDAAs) since they are different from those (i.e. D-alanine and D-glutamate) normally present in the bacterial cell wall. In V. cholerae, production of NCDAAs relies on the BsrV enzyme, a periplasmic broad spectrum racemase. BsrV multispecific activity, produces of a wide range of distinct D-amino acids. Using a combination of genetics and molecular physiology approaches we have demonstrated that NCDAAs target different cellular processes which may function as part of a cooperative strategy in vibrio communities to protect non-producing members from competing bacteria. Because NCDAA production is widespread in bacteria, we anticipate that NCDAAs are relevant modulators of microbial subpopulations in diverse ecosystems (AU)
RESUMEN
No disponible
Texto completo:
1
Coleções:
06-national
/
ES
Base de dados:
IBECS
Assunto principal:
Vibrio cholerae
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Parede Celular
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Cólera
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Alanina
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Aminoácidos
Limite:
Female
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Humans
/
Male
Idioma:
En
Revista:
Int. microbiol
Ano de publicação:
2017
Tipo de documento:
Article