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Comparing the effects of fluticasone, anti-IgE and anti-TNF treatments in a chronic asthma model
Ozkars, MY; Keskin, O; Tokur, M; Ulasli, M; Gogebakan, B; Ciralik, H; Kucukosmanoglu, E; Demirel, C; Oztuzcu, S; Kahraman, H.
Afiliação
  • Ozkars, MY; Gaziantep University School of Medicine. Department of Pediatric Allergy and Immunology. Gaziantep. Turkey
  • Keskin, O; Gaziantep University School of Medicine. Department of Pediatric Allergy and Immunology. Gaziantep. Turkey
  • Tokur, M; Kahramanmaras Sutcu Imam University School of Medicine. Department of Thoracic Surgery. Kahramanmaras. Turkey
  • Ulasli, M; Gaziantep University School of Medicine. Department of Medical Biology. Gaziantep. Turkey
  • Gogebakan, B; Mustafa Kemal University School of Medicine. Department of Medical Biology. Hatay. Turkey
  • Ciralik, H; Kahramanmaras Sutcu Imam University School of Medicine. Department of Pathology. Kahrarmanmaras. Turkey
  • Kucukosmanoglu, E; Gaziantep University School of Medicine. Department of Pediatric Allergy and Immunology. Gaziantep. Turkey
  • Demirel, C; Gaziantep University School of Medicine. Department of Biophysics. Gaziantep. Turkey
  • Oztuzcu, S; Gaziantep University School of Medicine. Department of Medical Biology. Gaziantep. Turkey
  • Kahraman, H; Kahramanmaras Sutcu Imam University School of Medicine. Department of Pulmonology. Kahramanmaras. Turkey
Allergol. immunopatol ; 46(3): 226-234, mayo-jun. 2018. tab, graf
Article em En | IBECS | ID: ibc-172941
Biblioteca responsável: ES1.1
Localização: BNCS
ABSTRACT
BACKGROUND: Corticosteroids are used in the treatment of asthma. The aim of this study was to determine the efficacy of anti-IgE and anti-TNF alpha as asthma treatments. METHODS: A mouse model of chronic asthma was developed. The fluticasone group was exposed to fluticasone and the anti-IgE and anti-TNF groups were administered anti-IgE or anti-TNF. IL-4, and IgE levels were measured, and histological analysis, pathological analysis and miRNA-126, miRNA-133a analyses were applied. RESULTS: The cell concentration in the BAL fluid decreased in all the treatment groups. The rate of perivascular and peribronchial cell infiltration decreased in the lung in the high-dose anti-IgE and anti-TNF groups. Smooth muscle thickness decreased in the lung tissue in the low-dose anti-IgE and anti-TNF groups. Bronchial wall thickness decreased in the lung tissue in the fluticasone+anti-IgE group. The IL-4 level in BAL fluid decreased in the high-dose anti-IgE, fluticasone+anti-IgE and anti-TNF groups. IgE levels increased in the BAL fluid in the high-dose anti-IgE and anti-TNF groups. The lymphocyte level increased in the BAL fluid in the high-dose anti-IgE group. The macrophage level decreased in the BAL fluid in the anti-TNF group. The relative expression of miRNA-126 increased in all groups. The relative expression of miRNA-133a decreased in the placebo and fluticasone groups. The relative expression of miRNA-133a increased in the low-dose anti-IgE, high-dose anti-IgE, fluticasone+anti-IgE and anti-TNF groups. CONCLUSIONS: The results showed that anti-IgE is successful as a treatment. Fluticasone+anti-IgE and anti-TNF were seen to be superior to other therapeutic modalities when used for prophylaxis
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Coleções: 06-national / ES Base de dados: IBECS Assunto principal: Asma / Anticorpos Anti-Idiotípicos / Fator de Necrose Tumoral alfa / Antiasmáticos / Fluticasona Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Allergol. immunopatol Ano de publicação: 2018 Tipo de documento: Article
Buscar no Google
Coleções: 06-national / ES Base de dados: IBECS Assunto principal: Asma / Anticorpos Anti-Idiotípicos / Fator de Necrose Tumoral alfa / Antiasmáticos / Fluticasona Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Allergol. immunopatol Ano de publicação: 2018 Tipo de documento: Article