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Relationship between acute kidney injury and serum procalcitonin (PCT) concentration in critically ill patients with influenza infection / Relación entre disfunción renal aguda y valores séricos de procalcitonina en pacientes críticos con infección por gripe
Rodríguez, A; Reyes, LF; Monclou, J; Suberviola, B; Bodí, M; Sirgo, G; Solé-Violán, J; Guardiola, J; Barahona, D; Díaz, E; Martín-Loeches, I; Restrepo, MI.
Afiliação
  • Rodríguez, A; Hospital Universitari de Tarragona Joan XXIII. Critical Care Department. Tarragona. Spain
  • Reyes, LF; University of Texas Health Science Center at San Antonio. Division of Pulmonary Diseases and Critical Care Medicine. San Antonio. USA
  • Monclou, J; Hospital Universitari de Tarragona Joan XXIII. Critical Care Department. Tarragona. Spain
  • Suberviola, B; Hospital Universitario Marqués de Valdecilla. Critical Care Department. Santander. Spain
  • Bodí, M; Hospital Universitari de Tarragona Joan XXIII. Critical Care Department. Tarragona. Spain
  • Sirgo, G; Hospital Universitari de Tarragona Joan XXIII. Critical Care Department. Tarragona. Spain
  • Solé-Violán, J; Hospital Dr. Negrín. Critical Care Department. Las Palmas de Gran Canaria. Spain
  • Guardiola, J; University of Louisville. Division of Pulmonary, Critical Care and Sleep Medicine. Robley Rex VA Medical Center. Louisville. USA
  • Barahona, D; Hospital Docente de Calderón. Critical Care Department. Quito. Ecuador
  • Díaz, E; ParcTaulí Hospital. Critical Care Department. Centro de investigación en red de enfermedades respiratorias (CIBERes). Sabadell. Spain
  • Martín-Loeches, I; St James's University Hospital. Department of Anaesthesia and Critical Care. Trinity Centre for Health Sciences. Multidisciplinary Intensive Care Research Organization (MICRO). Dublin. Ireland
  • Restrepo, MI; University of Texas Health Science Center at San Antonio. Division of Pulmonary Diseases and Critical Care Medicine. San Antonio. USA
Med. intensiva (Madr., Ed. impr.) ; 42(7): 399-408, oct. 2018. tab, graf
Article em En | IBECS | ID: ibc-178658
Biblioteca responsável: ES1.1
Localização: BNCS
ABSTRACT
INTRODUCTION: Serum procalcitonin (PCT) concentration could be increased in patients with renal dysfunction in the absence of bacterial infection. OBJECTIVE: To determine the interactions among serum renal biomarkers of acute kidney injury (AKI) and serum PCT concentration, in patients admitted to the intensive care unit (ICU) due to lung influenza infection. DESIGN: Secondary analysis of a prospective multicentre observational study. SETTING: 148 Spanish ICUs. PATIENTS: ICU patients admitted with influenza infection without bacterial co-infection. Clinical, laboratory and hemodynamic variables were recorded. AKI was classified as AKI I or II based on creatinine (Cr) concentrations (≥1.60-2.50mg/dL and Cr≥2.51-3.99mg/dL, respectively). Patients with chronic renal disease, receiving renal replacement treatment or with Cr>4mg/dL were excluded. Spearman's correlation, simple and multiple linear regression analysis were performed. INTERVENTIONS: None. RESULTS: Out of 663 patients included in the study, 52 (8.2%) and 10 (1.6%) developed AKI I and II, respectively. Patients with AKI were significantly older, had more comorbid conditions and were more severally ill. PCT concentrations were higher in patients with AKI (2.62 [0.60-10.0]ng/mL vs. 0.40 [0.13-1.20]ng/mL, p = 0.002). Weak correlations between Cr/PCT (rho=0.18) and Urea (U)/PCT (rho=0.19) were identified. Simple linear regression showed poor interaction between Cr/U and PCT concentrations (Cr R2=0.03 and U R2=0.018). Similar results were observed during multiple linear regression analysis (Cr R2=0.046 and U R2=0.013). CONCLUSIONS: Although PCT concentrations were slightly higher in patients with AKI, high PCT concentrations are not explained by AKI and could be warning sign of a potential bacterial infection
RESUMEN
INTRODUCCIÓN: Los niveles de procalcitonina (PCT) pueden elevarse en pacientes con disfunción renal aún en ausencia de infección bacteriana. OBJETIVOS: Determinar la interacción entre los biomarcadores de disfunción renal aguda (AKI) y las concentraciones séricas de PCT en pacientes ingresados en cuidados intensivos (UCI) debido a infección por gripe. DISEÑO: Análisis secundario de un estudio prospectivo, multicéntrico observacional. Lugar: Ciento cuarenta y ocho UCI. PACIENTES: Con infección por gripe sin co-infección bacteriana. Se registraron las variables clínicas, de laboratorio y hemodinámicas. El nivel de AKI fue definido como AKI I y II basado en la creatinina (Cr) sérica (>1,60-2,50mg/dl y >2,51-3,99mg/dl), respectivamente. Pacientes con insuficiencia renal crónica, técnicas de reemplazo renal o Cr>4mg/dl fueron excluidos. El análisis estadístico se realizó mediante correlación de Spearman y regresión linear simple y múltiple. INTERVENCIONES: Ninguna. RESULTADOS: De los 663 pacientes incluidos, 52 (8,2%) y 10 (1,6%) desarrollaron AKI I y II, respectivamente. Pacientes con AKI fueron más añosos, presentaron más comorbilidades y mayor nivel de gravedad. Los niveles de PCT fueron mayores en pacientes con AKI (2,62 [0,60-10,0] ng/ml vs. 0,40 [0,13-1,20] ng/ml; p = 0,002). Se observaron correlaciones débiles entre Cr/PCT (rho=0,18) y PCT/U (rho=0,19). La regresión linear simple evidenció una pobre contribución tanto de Cr (R2=0,03) como de U (R2=0,018) sobre los niveles de PCT. Resultados similares fueron obtenidos con la regresión linear múltiple para Cr (R2=0,046) y U (R2=0,013). CONCLUSIONES: Aunque los valores de PCT pueden estar elevados en pacientes con AKI, altos niveles de PCT no pueden ser explicados por la disfunción renal y podrían ser un signo de alarma de una potencial infección bacteriana
Assuntos

Texto completo: 1 Coleções: 06-national / ES Base de dados: IBECS Assunto principal: Infecções Bacterianas / Calcitonina / Estado Terminal / Influenza Humana / Injúria Renal Aguda / Coinfecção Limite: Adult / Female / Humans / Male Idioma: En Revista: Med. intensiva (Madr., Ed. impr.) Ano de publicação: 2018 Tipo de documento: Article

Texto completo: 1 Coleções: 06-national / ES Base de dados: IBECS Assunto principal: Infecções Bacterianas / Calcitonina / Estado Terminal / Influenza Humana / Injúria Renal Aguda / Coinfecção Limite: Adult / Female / Humans / Male Idioma: En Revista: Med. intensiva (Madr., Ed. impr.) Ano de publicação: 2018 Tipo de documento: Article