Cell source, differentiation, functional stimulation, and potential application of human thermogenic adipocytes in vitro
J. physiol. biochem
; 73(3): 315-321, ago. 2017. tab, graf
Artigo
em Inglês
| IBECS
| ID: ibc-178883
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
Recent investigations have showed that the functional thermogenic adipocytes are present in both infants and adult humans. Accumulating evidence suggests that the coexistence of classical and inducible brown (brite) adipocytes in humans at adulthood and these adipocytes function to generate heat from energy resulting in reducing body fat and improving glucose metabolism. Human thermogenic adipocytes can be differentiated in vitro from stem cells, cell lines, or adipose stromal vascular fraction. Pre-activated human brite adipocytes in vitro can maintain their thermogenic function in normal or obese immunodeficient mice; therefore, they improve glucose homeostasis and reduce fat mass in obese animals. These key findings have opened a new door to use in vitro thermogenic adipocytes as a cell therapy to prevent obesity and related disorders. Thus, this paper intends to highlight our knowledge in aspects of in vitro human brite/brown adipocytes for the further studies
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Espanha
Base de dados:
IBECS
Assunto principal:
Adipócitos
/
Transplante de Células-Tronco
Limite:
Animais
/
Humanos
Idioma:
Inglês
Revista:
J. physiol. biochem
Ano de publicação:
2017
Tipo de documento:
Artigo
Instituição/País de afiliação:
Duy Tan University/Vietnam
/
Nanjing Agricultural University/Vietnam
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VINMEC Research Institute of Stem Cell and Gene Technology/Vietnam
/
Vietnam National University/Vietnam