Mineralocorticoid receptor antagonism protects the aorta from vascular smooth muscle cell proliferation and collagen deposition in a rat model of adrenal aldosterone-producing adenoma
J. physiol. biochem
; 74(1): 17-24, feb. 2018. tab, graf, ilus
Artigo
em Inglês
| IBECS
| ID: ibc-178914
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
The number of patients with adrenal aldosterone-producing adenomas (APAs) has gradually increased. However, even after adenoma resection, some patients still suffer from high systolic blood pressure (SBP), which is possibly due to great arterial remodeling. Moreover, mineralocorticoid receptors (MRs) were found to be expressed in vascular smooth muscle cells (VSMCs). This study aims to determine whether MR antagonism protects the aorta from aldosterone-induced aortic remolding. Male rats were subcutaneously implanted with an osmotic minipumps and randomly divided into four groups control; aldosterone (1 μg/h); aldosterone plus a specific MR antagonist, eplerenone (100 mg/kg/day); and aldosterone plus a vasodilator, hydralazine (25 mg/kg/day). After 8 weeks of infusion, aortic smooth muscle cell proliferation and collagen deposition, as well as the MDM2 and TGF-Beta1 expression levels in the aorta, were examined. Model rats with APAs were successfully constructed. Compared with the control rats, the model rats exhibited (1) marked SBP elevation, (2) no significant alteration in aortic morphology, (3) increased VSMC proliferation and MDM2 expression in the aorta, and (4) enhanced total collagen and collagen III depositions in the aorta, accompanied with up-regulated expression of TGF- Beta1. These effects were significantly inhibited by co-administration with eplerenone but not with hydralazine. These findings suggested that specific MR antagonism protects the aorta from aldosterone-induced VSMC proliferation and collagen deposition
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Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Espironolactona
/
Colágeno
/
Modelos Animais de Doenças
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Antagonistas de Receptores de Mineralocorticoides
/
Corticotrofos
/
Hipertensão
Limite:
Animais
Idioma:
Inglês
Revista:
J. physiol. biochem
Ano de publicação:
2018
Tipo de documento:
Artigo
Instituição/País de afiliação:
Beijing University of Chinese Medicine/Republic of China
/
First Affiliated Hospital of Xiamen University/Republic of China
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First People's Hospital of Jining City/Republic of China
/
First Peoples Hospital of Yunnan Province/Republic of China
/
Military Postgraduate Medical College/Republic of China