Atomoxetine enhances memory and proliferation in adult male rat hippocampus
Eur. j. anat
; 23(4): 243-251, jul. 2019. ilus, graf
Artigo
em Inglês
| IBECS
| ID: ibc-182997
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
Atomoxetine (ATX) is a noradrenaline reuptake inhibitor used to treat Attention deficit hyperactive syndrome (ADHD), or improve cognition in normal subjects. The cognitive effects of ATX require inputs from the hippocampus. Moreover, proliferation is said to be located in the dentate gyrus (DG) of the hippocampus.In the present study, we hypothesised that ATX improves memory and proliferation of the adult rat hippocampus. To test this hypothesis, 5 intraperitoneal injections of ATX (30 mg/kg/day) over 5 consecutive days were delivered to rats. 30 minutes after the last injection, spatial memory was tested using the Novel location recognition (NLR) test. Proliferation of hippocampal cells was quantified using immunohistochemistry for the proliferative marker Ki67. ATX-treated rats showed cognitive enhancement in the NLR task and increase in cell proliferation in the Subgranular zone (SGZ) of the DG, compared to saline-treated controls. The results demonstrate that ATX is able to enhance cognition through increasing the levels of proliferation in the adult rat brains
RESUMEN
No disponible
Texto completo:
Disponível
Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Transtorno do Deficit de Atenção com Hiperatividade
/
Cérebro
/
Cloridrato de Atomoxetina
/
Hipocampo
/
Estimulantes do Sistema Nervoso Central
Limite:
Animais
Idioma:
Inglês
Revista:
Eur. j. anat
Ano de publicação:
2019
Tipo de documento:
Artigo
Instituição/País de afiliação:
Menoufia University/Egypt
/
The University of Jordan/Jordan