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Evaluation of testicular cytotoxicity and genotoxicity of sofosbuvir and sofosbuvir - ribavirin in the adult male albino rats
El-Kholy, Wael B; Faried, Manar A; Salama, Rasha M; El-Fiky, Mohammed M; El-Garawani, Islam.
Afiliação
  • El-Kholy, Wael B; Menoufia University. Faculty of Medicine. Department of Anatomy and Embryology. Egypt
  • Faried, Manar A; Menoufia University. Faculty of Medicine. Department of Anatomy and Embryology. Egypt
  • Salama, Rasha M; Menoufia University. Faculty of Medicine. Department of Anatomy and Embryology. Egypt
  • El-Fiky, Mohammed M; Menoufia University. Faculty of Medicine. Department of Anatomy and Embryology. Egypt
  • El-Garawani, Islam; Menoufia University. Faculty of Science. Departament of Zoology. Egypt
Eur. j. anat ; 23(6): 393-403, nov. 2019. graf, ilus, tab
Article em En | IBECS | ID: ibc-185082
Biblioteca responsável: ES1.1
Localização: BNCS
ABSTRACT
Hepatitis C is a widely distributed problem all over the world, especially Egypt. Chronically infected people develop serious liver disease and now it is the most common cause for liver transplantation. Recently, a new regimen, sofosbuvir (sovaldi), alone or with combinations as sovaldi-ribavirin, was approved for treating this disease. There are limited studies that explore the effects of these drugs on the reproductive organs, and hence affection of male fertility while using these drugs. This study aims to throw more light on whether sovaldi or sovaldi-ribavirin causes testicular damaging effects in the adult male albino rats. We investigated the effect of this regimen in a dose equivalent to that used in the human (41 mg/kg once daily orally for sovaldi and 41 mg/kg twice daily orally for ribavirin) for consecutive 5 and 10 days. There was highly significant decrease in testosterone hormone level and marked degenerative changes in the seminiferous tubules and the testicular interstitium, with increase in collagen deposits in sovaldi treated rats, and in a more extensive manner in sovaldi-ribavirin treated rats. There was a significant increase of deoxyribonucleic acid (DNA) fragmentation in the treated groups after 10 days. However, there was a non-significant difference in DNA fragmentation in the treated groups after 5 days when compared with control. Immuno-histochemistry detection of caspase-3 showed significant increase in its expression in the treated groups after either 5 or 10 days. This denoted the specificity of caspase-3 immunohistochemistry technique in the detection of early apoptotic changes. It was concluded that sovaldi and sovaldi ribavirin induced gonado toxic effects through induction of DNA fragmentation via up regulation of caspase-3, and that the resulting damaging effects increased with longer duration of drug in take
RESUMEN
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Assuntos
Texto completo: 1 Coleções: 06-national / ES Base de dados: IBECS Assunto principal: Ribavirina / Testículo / Hepatite C / Disruptores Endócrinos / Sofosbuvir Limite: Animals Idioma: En Revista: Eur. j. anat Ano de publicação: 2019 Tipo de documento: Article
Texto completo: 1 Coleções: 06-national / ES Base de dados: IBECS Assunto principal: Ribavirina / Testículo / Hepatite C / Disruptores Endócrinos / Sofosbuvir Limite: Animals Idioma: En Revista: Eur. j. anat Ano de publicação: 2019 Tipo de documento: Article