Effects of probiotics in the treatment of food hypersensitivity in children: a systematic review
Allergol. immunopatol
; 48(1): 95-104, ene.-feb. 2020. tab, graf
Artigo
em Inglês
| IBECS
| ID: ibc-186599
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
Introduction:
Food allergy is considered a public health problem for children. The modulation of the intestinal microbiota seems a promising strategy for the control of allergic reactions.Objective:
To describe the effects of different forms of probiotics in pediatric food hypersensitivity treatment. Data source We conducted a systematic review based on clinical trials published in the PubMed and Web of Science databases. The searches were carried out using the MeSH terms "Food Hypersensitivity", "Probiotics," "Lactobacillus", and "Bifidobacterium". Datasynthesis:
The final selection resulted in 18 clinical trials, which were predominantly samples of infants and pre-school children. The most-often used strain, either alone or in combination, was Lactobacillus rhamnosus GG; a placebo was mainly used in the control group. As for the vehicle, the most common forms were capsules and infant formulas, and the period of intervention ranged from four weeks to 24 months, with weekly or monthly visits to measure the outcomes. In these 18 trials, 46 analyses were performed with 27 different types of outcomes to evaluate the effects of probiotics (12 laboratory and 15 clinical). Twenty-seven of these analyses demonstrated the benefits of using these microorganisms. The SCORAD (atopic dermatitis index) and IgE levels and cytokines were the outcomes mostly evaluated.Conclusion:
The use of probiotics is beneficial in promoting immunomodulation and reducing clinical symptoms. However, more methodologically based research is needed to clarify the effect from each type, dose, and time of using them for the establishment of definitive care protocolsRESUMEN
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Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Probióticos
/
Imunomodulação
/
Microbioma Gastrointestinal
/
Hipersensibilidade Alimentar
Limite:
Adolescente
/
Criança
/
Humanos
Idioma:
Inglês
Revista:
Allergol. immunopatol
Ano de publicação:
2020
Tipo de documento:
Artigo
Instituição/País de afiliação:
UNIFESP)+Brazil