Impact of select risk factors on treatment outcome in adults with candidemia
Pharm. pract. (Granada, Internet)
; 17(3): 0-0, jul.-sept. 2019. tab, graf
Artigo
em Inglês
| IBECS
| ID: ibc-188126
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
Background:
Studies examining relationships between patient-related factors and treatment outcome in patients with candidemia are limited and often based on all-cause mortality.Objective:
Our purpose was to examine the impact of concurrent renal replacement therapy (RRT) and other pre-specified factors on treatment outcome among adults with candidemia.Methods:
This Institutional Review Board (IRB)-approved, single-center, case-cohort study included patients over 18 years of age admitted to Duke University Hospital between Jun 1, 2013 and Jun 1, 2017 with a blood culture positive for Candida spp. Treatment-, patient-, and disease-specific data were collected, and outcome (success/failure) determined 90 days after the index culture. An odds ratio (OR) and 95% confidence interval (95%CI) were calculated for the following during therapy receipt of RRT, fluconazole monotherapy regimen, intensive care unit (ICU) stay, and neutropenia.Results:
Among the 112 encounters (from 110 unique patients) included, treatment failure occurred in 8/112 (7.1%). Demographics were comparable between outcome groups. Among 12 patients receiving concomitant RRT, only 1 patient failed therapy. With regard to treatment failure, no significant differences were observed with RRT (OR, 1.21; 95%CI, 0.14 - 10.75), fluconazole monotherapy regimen (OR, 1.59; 95%CI, 0.3-8.27), ICU stay (OR, 1.43; 95%CI, 0.32-6.29), and neutropenia (0 treatment failures).Conclusions:
Treatment failure, receipt of concomitant RRT, and neutropenia were infrequent in patients undergoing treatment for candidemia. In our cohort, exposure to RRT, a fluconazole monotherapy regimen, ICU stay, or neutropenia during treatment did not impact treatmentoutcome:
RESUMEN
No disponible
Texto completo:
Disponível
Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Candida
/
Candidíase
/
Terapia de Substituição Renal
/
Candidemia
/
Neutropenia
Limite:
Adolescente
/
Adulto
/
Idoso
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Pharm. pract. (Granada, Internet)
Ano de publicação:
2019
Tipo de documento:
Artigo
Instituição/País de afiliação:
Campbell University/United States
/
University of Virginia Medical Center/United States