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Safety and tolerability of ceftobiprole
Grau, Santiago.
Afiliação
  • Grau, Santiago; Universitat Autònoma de Barcelona. Hospital del Mar. Pharmacy Service. Bellaterra. Spain
Rev. esp. quimioter ; 32(supl.3): 34-36, sept. 2019. tab
Article em En | IBECS | ID: ibc-188977
Biblioteca responsável: ES1.1
Localização: BNCS
ABSTRACT
Ceftobiprole is a fifth generation cephalosporin with a series of characteristics differentiating it from other beta-lactams, including its antibacterial activity, mainly against methicillin-resistant Staphylococcus aureus, resistant Streptococcus pneumoniae and also Gram-negative microorganisms such as Pseudomonas aeruginosa. This antibiotic has been subjected to various clinical trials and the results of these have led to its approval in Spain for the treatment of nosocomial pneumonia, excluding that associated with mechanical ventilation, and community-acquired pneumonia. The results of various ceftobiprole clinical studies provide consistent information on efficacy and tolerability. Ceftobiprole as monotherapy has been shown to be non-inferior to comparator antibiotics in different settings. Information is available on its compatibility with other drugs in Y-site administration, important from the point of view of the intravenous treatment of patients who present venous access limitation. On the other hand, and in contrast to other cephalosporins, ceftobiprole presents a low risk of infection due to Clostridium difficile and, in comparison with ceftaroline, neutropenia has not been reported to present any significant issues
RESUMEN
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Assuntos
Texto completo: 1 Coleções: 06-national / ES Base de dados: IBECS Assunto principal: Cefalosporinas / Antibacterianos Limite: Humans Idioma: En Revista: Rev. esp. quimioter Ano de publicação: 2019 Tipo de documento: Article
Texto completo: 1 Coleções: 06-national / ES Base de dados: IBECS Assunto principal: Cefalosporinas / Antibacterianos Limite: Humans Idioma: En Revista: Rev. esp. quimioter Ano de publicação: 2019 Tipo de documento: Article