IgE-mediated sensitization to galactose-alfa-1.3-galactose (alfa-Gal) in urticaria and anaphylaxis in Spain: geographical variations and risk factors
J. investig. allergol. clin. immunol
; 29(6): 436-443, 2019. tab, graf
Artigo
em Inglês
| IBECS
| ID: ibc-189780
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
BACKGROUND:
The objectives of this study were to investigate the prevalence of sIgE to galactose-alfa-1,3-galactose (alfa-gal) in individuals with acute urticaria or anaphylaxis from different geographical areas of Spain and to evaluate the relevance of demographics and lifestyle as risk factors for this immune response.METHODS:
Participants were recruited from allergy departments at 14 Spanish hospitals. Patients aged 18 years or older presenting with urticaria or anaphylaxis were enrolled into one of 2 arms cases and controls. An interviewer-administered questionnaire collecting demographic data, lifestyle habits, and the presence of cofactors was obtained from each participant. sIgE to alfa-gal and total IgE were determined using ImmunoCAP. sIgE levels ≥0.35 kU/L were considered a positive result.RESULTS:
The study population comprised 160 cases and 126 controls. The median age was 44 years. The overall prevalence of a positive result of sIgE to alfa-gal was 15.7%; this was higher in cases (26.3%) than in controls (2.4%). The sIgE anti-alfa-gal positivity rate ranged from 37.68% (rural) to 15.38% (semiurban), and 7.85% (urban). The rates of positivity were 46.32%, (Northern), 0.72% (Center), and 0% (Mediterranean). A positive result for sIgE to alfa-gal was associated with a history of tick bites, participation in outdoor activities, pet ownership, and ingestion of mammalian meats or innards before the onset of symptoms. Only alcohol consumption could be implicated as a cofactor.CONCLUSION:
Sensitization to alfa-gal in patients with urticaria or anaphylaxis differs considerably between the 3 geographical areas studied and is related to tick bites
Texto completo:
Disponível
Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Urticária
/
Imunoglobulina E
/
Alérgenos
/
Doenças Transmitidas por Carrapatos
/
Dissacarídeos
/
Hipersensibilidade
/
Anafilaxia
Limite:
Adulto
/
Feminino
/
Humanos
/
Masculino
País/Região como assunto:
Europa
Idioma:
Inglês
Revista:
J. investig. allergol. clin. immunol
Ano de publicação:
2019
Tipo de documento:
Artigo
Instituição/País de afiliação:
Complejo Hospitalario de Navarra/Spain
/
Hospital Clinic/Spain
/
Hospital La Zarzuela/Spain
/
Hospital Marina Baixa/Spain
/
Hospital Universitari de la Vall d'Hebron/Spain
/
Hospital Universitario Central de Asturias/Spain
/
Hospital Universitario Fundación de Alcorcón/Spain
/
Hospital Universitario Lucus Augusti/Spain
/
Hospital Universitario de Fuenlabrada/Spain
/
Hospital Universitario de Guadalajara/Spain