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Higher levels of serum uric acid influences hepatic damage in patients with non-alcoholic fatty liver disease (NAFLD)
Fernández Rodríguez, Conrado M; Aller, Rocío; Gutiérrez García, María Luisa; Ampuero, Javier; Gómez-Camarero, Judith; Martín-Mateos, Rosa M; Burgos-Santamaría, Diego; Rosales, José Miguel; Aspichueta, Patricia; Buque, Xabier; Latorre, Mercedes; Andrade, Raúl J; Hernández-Guerra, Manuel; Romero-Gómez, Manuel.
Afiliação
  • Fernández Rodríguez, Conrado M; Hospital Universitario Fundación Alcorcón. Digestive Diseases Unit. Alcorcón. Spain
  • Aller, Rocío; Hospital Clinic. Valladolid. Spain
  • Gutiérrez García, María Luisa; Hospital Universitario Fundación Alcorcón. Digestive Diseases Unit. Alcorcón. Spain
  • Ampuero, Javier; Hospital Universitario Virgen del Rocío. Unit for the Clinical Management of Digestive Diseases. Sevilla. Spain
  • Gómez-Camarero, Judith; Hospital Universitario. Burgos. Spain
  • Martín-Mateos, Rosa M; Universidad de Alcalá de Henares. Hospital Universitario Ramón y Cajal. Madrid. Spain
  • Burgos-Santamaría, Diego; Universidad de Alcalá de Henares. Hospital Universitario Ramón y Cajal. Madrid. Spain
  • Rosales, José Miguel; Agencia Sanitaria Costa del Sol. Unit of Gastroenterology. Marbella. Spain
  • Aspichueta, Patricia; Universidad del País Vasco (UPV/EHU). Biocruces Health Research Institute. Barakaldo. Spain
  • Buque, Xabier; Universidad del País Vasco (UPV/EHU). Biocruces Health Research Institute. Barakaldo. Spain
  • Latorre, Mercedes; Hospital General Universitario Consortium. Valencia. Spain
  • Andrade, Raúl J; Universidad de Málaga. Hospital Universitario Virgen de la Victoria. Málaga. Spain
  • Hernández-Guerra, Manuel; Hospital Universitario de Tenerife. San Cristóbal de La Laguna. Spain
  • Romero-Gómez, Manuel; Hospital Universitario Virgen del Rocío. Unit for the Clinical Management of Digestive Diseases. Sevilla. Spain
Rev. esp. enferm. dig ; 111(4): 264-269, abr. 2019. tab, graf
Article em Es | IBECS | ID: ibc-189922
Biblioteca responsável: ES1.1
Localização: BNCS
ABSTRACT
Background: recent evidence suggests a causal link between serum uric acid and the metabolic syndrome, diabetes mellitus, arterial hypertension, and renal and cardiac disease. Uric acid is an endogenous danger signal and activator of the inflammasome, and has been independently associated with an increased risk of cirrhosis. Aim and methods: six hundred and thirty-four patients from the nation-wide HEPAMET registry with biopsy-proven NAFLD (53% NASH) were analyzed to determine whether hyperuricemia is related with advanced liver damage in patients with non-alcoholic fatty liver disease (NAFLD). Patients were divided into three groups according to the tertile levels of serum uric acid and gender. Results: the cohort was composed of 50% females, with a mean age of 49 years (range 19-80). Patients in the top third of serum uric acid levels were older (p = 0.017); they had a higher body mass index (p < 0.01), arterial blood pressure (p = 0.05), triglyceridemia (p = 0.012), serum creatinine (p < 0.001) and total cholesterol (p = 0.016) and lower HDL-cholesterol (p = 0.004). According to the univariate analysis, the variables associated with patients in the top third were more advanced steatosis (p = 0.02), liver fibrosis (F2-F4 vs F0-1; p = 0.011), NASH (p = 0.002) and NAS score (p = 0.05). According to the multivariate logistic regression analysis, the top third of uric acid level was independently associated with steatosis (adjusted hazard ratio 1.7; CI 95%: 1.05-2.8) and NASH (adjusted hazard ratio 1.8; CI 95%: 1.08-3.0) but not with advanced fibrosis (F2-F4) (adjusted hazard ratio 1.09; CI 95%: 0.63-1.87). Conclusion: higher levels of serum uric acid were independently associated with hepatocellular steatosis and NASH in a cohort of patients with NAFLD. Serum uric acid levels warrants further evaluation as a component of the current non-invasive NAFLD scores of histopathological damage
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Coleções: 06-national / ES Base de dados: IBECS Assunto principal: Hipertrigliceridemia / Hiperuricemia / Fígado Gorduroso / Hepatopatia Gordurosa não Alcoólica / Hipercolesterolemia Limite: Adult / Aged / Female / Humans / Male Idioma: Es Revista: Rev. esp. enferm. dig Ano de publicação: 2019 Tipo de documento: Article
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Coleções: 06-national / ES Base de dados: IBECS Assunto principal: Hipertrigliceridemia / Hiperuricemia / Fígado Gorduroso / Hepatopatia Gordurosa não Alcoólica / Hipercolesterolemia Limite: Adult / Aged / Female / Humans / Male Idioma: Es Revista: Rev. esp. enferm. dig Ano de publicação: 2019 Tipo de documento: Article