The effect of Salvia miltiorrhiza in a mouse model of hepatic sinusoidal obstruction syndrome induced by Gynura segetum
Rev. esp. enferm. dig
; 111(11): 823-827, nov. 2019. ilus, tab, graf
Artigo
em Inglês
| IBECS
| ID: ibc-190504
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
Background and aims:
to investigate the potential effect and mechanism of Salvia miltiorrhiza in Gynura segetum-induced hepatic sinusoidal obstruction syndrome (HSOS).Methods:
the mice were gavaged with PBS, Gynura segetum or Gynura segetum, along with 100 or 200 mg/kg Salvia miltiorrhiza. Histological scoring and liver function were performed. The expression of tumor necrosis factor-alpha (TNF-alfa), vascular cellular adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1) and nuclear transcription factor P65 (NF-κBp65) were determined by reverse transcriptase polymerase chain reaction (RT-PCR) and western blot.Results:
liver function were effectively improved in the Salvia miltiorrhiza groups. The levels of TNF-alfa, VCAM-1, ICAM-1 and NF-κBp65 were significantly lower in the Salvia miltiorrhiza groups than in the Gynura segetum group.Conclusions:
Salvia miltiorrhiza has a therapeutic effect on Gynura segetum-induced HSOSRESUMEN
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Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Hepatopatia Veno-Oclusiva
/
Extratos Vegetais
/
Moléculas de Adesão Celular
/
Fator de Necrose Tumoral alfa
/
Molécula 1 de Adesão de Célula Vascular
/
Salvia miltiorrhiza
/
Fator de Transcrição RelA
Limite:
Animais
Idioma:
Inglês
Revista:
Rev. esp. enferm. dig
Ano de publicação:
2019
Tipo de documento:
Artigo
Instituição/País de afiliação:
Central South University/China
/
Hunan Normal University/China