Insulinoma masquerading as neurologic disease - Case report and review of the literature
Galicia clin
; 81(2): 54-56, abr. 2020. ilus, tab
Artigo
em Inglês
| IBECS
| ID: ibc-195199
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
Insulinomas are the most frequent etiology of hypoglycemia in a non-diabetic patient and the most common functional neuroendocrine tumors of the pancreas, with an annual incidence of about 4 cases per million. The majority of insulinomas are "well-differentiated endocrine tumors" or grade 1 tumors, as defined by World Health Organization. Most tumors are benign, solitary and occur sporadically. However, about 10% are associated with multiple endocrine neoplasia type 1 (MEN-1). Despite the majority being benign tumors, hypoglycemic symptoms caused by the hyperinsulinemia are frequently debilitating. Whipple triad (hypoglycemia, symptoms of hypoglycemia - either adrenergic or neuroglycopenic - and relief of these symptoms after administration of glucose) is usually present and should alert to the diagnosis.After the diagnosis is made, locating the tumor can be challenging because most tumors are small. Nonetheless, locating the tumor is crucial, once the only definite treatment is surgical excision. The majority of patients reach normalization of glucose levels after surgery. Incomplete resection leads to persistent symptoms and although uncommon in sporadic insulinomas, recurrence can be as high as 20% in patients with MEN-1 syndrome
RESUMEN
No disponible
Texto completo:
Disponível
Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Tumores Neuroendócrinos
/
Hipoglicemia
/
Insulinoma
Limite:
Adulto
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Galicia clin
Ano de publicação:
2020
Tipo de documento:
Artigo
Instituição/País de afiliação:
Espinho+Portugal