Marked shifts in gut microbial structure and neurotransmitter metabolism in fresh inmates revealed a close link between gut microbiota and mental health: A case-controlled study
Int. j. clin. health psychol. (Internet)
; 22(3): 1-10, Sept. - dec. 2022. tab, ilus, graf
Artigo
em Inglês
| IBECS
| ID: ibc-208424
Biblioteca responsável:
ES1.1
Localização: ES15.1 - BNCS
ABSTRACT
Background/Objective:
The gut microbiota plays a pivotal role in psychological health, but the mechanistic perspective between gut microbiome and mental health remains poorly understoodMethod:
The present case-controlled study recruited 30 unimprisoned subjects and 31 inmates that had been detained in jail for no more than a month. The mental health status, gut microbiota and blood NH3, H2S, 5-hydroxy trptamine and dopamine levels were measured.Results:
Compared with unimprisoned controls, the fresh inmates exhibited significantly higher scores on anxiety and depression. Both phylogenetic structure and functional genes of the gut microbiota markedly shifted in inmates. Inmates was more Bacteroides-dominated, while unimprisoned subjects were more Prevotella-dominated. Short-chain fatty acids (SCFAs)-producing genera were largely decreased in inmates and were negatively related to mental disorder scores, while Bacteroidetes and Proteobacteria were positive to anxiety and depression scores. Simultaneously, the inmates possessed reduced genes that participate in amino acids, carbohydrates and vitamin cofactors metabolism, but enriched genes that involved in the neurotransmitter-producing Shikimate pathway. Correlation analysis revealed that Anaerotruncus and Prevotella were negative to depression score, and Enterococcus was negative to anxiety score.Conclusions:
Our results revealed potential link between gut microbiota and mental health, leading further support to the microbiotagutbrain axis theory. (AU)
Texto completo:
Disponível
Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Prisioneiros
/
Saúde Mental
/
Microbioma Gastrointestinal
Limite:
Adulto
/
Humanos
/
Masculino
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Int. j. clin. health psychol. (Internet)
Ano de publicação:
2022
Tipo de documento:
Artigo
Instituição/País de afiliação:
Chinese Academy of Medical Sciences & Peking Union Medical College/China
/
Chinese Academy of Sciences/China
/
Cornell University/USA
/
Fuwai Hospital/China
/
Tianjin University of Traditional Chinese Medicine/PR China
/
University of Oklahoma/USA