Mechanism of action of cefiderocol
Rev. esp. quimioter
; 35(supl. 2): 16-19, Sept. 2022. ilus
Artigo
em Inglês
| IBECS
| ID: ibc-210689
Biblioteca responsável:
ES1.1
Localização: ES15.1 - BNCS
ABSTRACT
Gram-negative bacilli are intrinsically resistant to many antibiotics due to the low permeability of their outer membrane. The most effective strategy to solve this problem has been the design of antibiotics that cross the membrane using specific transport systems. This is the case of cefiderocol, which, unlike cefepime or ceftazidime, has a chlorocatechol group at the end of the C-3 side chain. This group is recognized by transporters located in the outer membrane that allow cefiderocol to accumulate in the periplasmic space. Furthermore, cefiderocol is not a substrate for efflux pumps and the configuration of the side chains at C-7 and in particular at C-3 confer it a high stability against hydrolysis by most beta-lactamases of clinical interest including class A (KPC, BLEEs), C (ampC) or D (OXA-48) serine beta-lactamases and metallo-betalactamases (NDM, VIM. IMP). In order to better understand the mechanism of action of cefiderocol, the importance of iron in bacterial metabolism and the competition for iron between bacteria and host are reviewed. (AU)
Texto completo:
Disponível
Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Cefalosporinas
/
Bactérias Gram-Negativas
/
Antibacterianos
Limite:
Humanos
Idioma:
Inglês
Revista:
Rev. esp. quimioter
Ano de publicação:
2022
Tipo de documento:
Artigo
Instituição/País de afiliação:
Universidad de Barcelona/España