Eosinophilic Esophagitis due to Aeroallergens: A Systematic Review and Update
J. investig. allergol. clin. immunol
; 32(6): 438-450, 2022. ilus, tab
Artigo
em Inglês
| IBECS
| ID: ibc-213395
Biblioteca responsável:
ES1.1
Localização: ES15.1 - BNCS
ABSTRACT
Eosinophilic esophagitis is a chronic antigen-mediated esophageal disease characterized clinically by symptoms related to esophageal dysfunction and histologically by TH2 inflammation (at least 15 eosinophils/high power field) when other secondary systemic and local causes of esophageal eosinophilia are excluded. Although this disease was initially ascribed to a delayed reaction to food allergens, emerging evidence suggests that aeroallergens may also play a role in pathogenesis and disease course. Some studies support seasonal variations in the diagnosis of eosinophilic esophagitis and disease exacerbations owing to the increase in aeroallergens to which patients are sensitized. It is also known that this disease can be caused by extensive, identifiable exposure to aeroallergens and after treatment with specific immunotherapy based on food or aeroallergens. It was recently postulated that treatment of allergic rhinoconjunctivitis can improve the symptoms of eosinophilic esophagitis, although data are limited to case reports and small series. Currently, biomarkers and biologic therapies are not helpful for diagnosis or inducing clinical and histological remission of the disease. Nevertheless, there are high hopes for dupilumab. This review aims to give visibility to the involvement of aeroallergens in the triggering and exacerbation of eosinophilic esophagitis, since many of them, in addition to being airborne and inhalant, can also be ingested as food. Clearly, we must try to identify the cause of the disease to ensure remission. (AU)
Texto completo:
Disponível
Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Alérgenos
/
Rinite Alérgica Sazonal
/
Esofagite Eosinofílica
Limite:
Humanos
Idioma:
Inglês
Revista:
J. investig. allergol. clin. immunol
Ano de publicação:
2022
Tipo de documento:
Artigo
Instituição/País de afiliação:
Hospital General Universitario/Spain