Severe Cutaneous Adverse Reactions to Drugs in Latin America: The RACGRAD Study
J. investig. allergol. clin. immunol
; 31(4): 322-331, 2021. tab, graf
Artigo
em Inglês
| IBECS
| ID: ibc-215224
Biblioteca responsável:
ES1.1
Localização: ES15.1 - BNCS
ABSTRACT
Background:
Severe cutaneous adverse reactions to drugs (SCARs) are associated with high morbidity and mortality and with sequelae.Objective:
To characterize patients with SCARs in 8 health care institutions in Latin America.Methods:
We performed a cross-sectional, descriptive, multicenter study of patients diagnosed with SCARs in Latin America between January 2009 and December 2018. The analysis was carried out using a database in BD Clinic.Results:
We collected 70 patients, of whom 42 (60%) were women. Mean age was 38.7 years. Forty-two patients (60%) had DRESS-DIHS, 12 (17.1%) TEN, 5 (7.1%) SJS, 6 (8.5%) AGEP, 4 (5.7%) other reactions not classified as SCARs, and 1 (1.4%) overlapping SJS-TEN. The main causative drugs were aromatic anticonvulsants in 31 cases (44.3%), ß-lactam antibiotics in 11 cases (15.7%), and nonß-lactam antibiotics in 6 cases (8.6%). In all of the cases, the suspected drug was withdrawn at the first sign of a SCAR. Sixty-six patients (94.2%) received anti-inflammatory treatment, mostly systemic corticosteroids. Complications occurred in 53 cases (75.7%), and 3 patients died (4.3%). Thirteen patients (18.6%) had sequelae.Conclusions:
This is the first multicenter report on SCARs in Latin America. DRESS-DIHS was the most frequently reported clinical entity, and anticonvulsants were the main triggers. Most of the patients received systemic corticosteroids. Complications were frequent, and 3 patients died (AU)
Texto completo:
Disponível
Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Erupção por Droga
/
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos
Limite:
Adulto
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
J. investig. allergol. clin. immunol
Ano de publicação:
2021
Tipo de documento:
Artigo
Instituição/País de afiliação:
Hospital Central/Paraguay
/
Hospital San Roque de Córdoba/Argentina
/
Hospital Universitario Austral/Argentina
/
Universidad Federal de São Paulo (UNIFESP)/Brasil
/
Universidad Icesi/Colombia
/
Universidad de Antioquia/Colombia
/
Universidad de São Paulo (USP)/Brasil