Mechanism of salidroside in the treatment of chronic myeloid leukemia based on the network pharmacology and molecular docking
Clin. transl. oncol. (Print)
; 25(2): 384-395, feb. 2023.
Artigo
em Inglês
| IBECS
| ID: ibc-215938
Biblioteca responsável:
ES1.1
Localização: ES15.1 - BNCS
ABSTRACT
Background Salidroside is a phenolic natural product, which is a kind of Rhodiola rosea. It has been confirmed that it has inhibitory effects on chronic myeloid leukemia, but the specific performance of its molecular effects is still unclear. Objective To systematically study the pharmacological mechanism of salidroside on chronic myeloid leukemia by means of network pharmacology. Methods First, the possible target genes of salidroside were predicted through the Traditional Chinese Medicine Pharmacology Database and Analysis Platform, the target gene names were converted into standardized gene names using the Uniprot website. At the same time, the related target genes of chronic myeloid leukemia were collected from GeneCards and DisGenet; Collect summary data and screen for commonly targeted genes. Then, the above-mentioned intersected genes were imported into the String website to construct the proteinprotein interaction (PPI) network, and the Gene Ontology (GO) functional annotation and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway were further analyzed. To investigate the overall pharmacological effects of salidroside on chronic myeloid leukemia, we constructed a drug componenttarget genedisease (CTD) network. Finally, molecular docking was performed to verify the possible binding conformation between salidroside and the candidate target. Results A total of 126 salidroside target genes were retrieved, and 106 of them had interactions with chronic myeloid leukemia. The pharmacological effects of salidroside on chronic myeloid leukemia are related to some important oncogenes and signaling pathways. Molecular docking studies confirmed that the main role of salidroside binding to the target genes is hydrogen bonding (AU)
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Coleções:
Bases de dados nacionais
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Espanha
Base de dados:
IBECS
Assunto principal:
Leucemia Mielogênica Crônica BCR-ABL Positiva
/
Simulação de Acoplamento Molecular
/
Glucosídeos
Limite:
Humanos
Idioma:
Inglês
Revista:
Clin. transl. oncol. (Print)
Ano de publicação:
2023
Tipo de documento:
Artigo
Instituição/País de afiliação:
The First Clinical Medical College of Lanzhou University/Peoples Republic of China