Histone methylation in pre-cancerous liver diseases and hepatocellular carcinoma: recent overview
Clin. transl. oncol. (Print)
; 25(6): 1594-1605, jun. 2023. ilus
Artigo
em Inglês
| IBECS
| ID: ibc-221192
Biblioteca responsável:
ES1.1
Localização: ES15.1 - BNCS
ABSTRACT
Hepatocellular carcinoma (HCC) is the prevalent form of liver cancer in adults and the fourth most common cause of cancer-related death worldwide. HCC predominantly arises in the context of cirrhosis as a result of chronic liver disease, injury and inflammation. Full-blown HCC has poor prognosis because it is highly aggressive and resistant to therapy. Consequently, interventions that can prevent or restrain HCC emergence from pre-cancerous diseased liver are a desirable strategy. Histone methylation is a dynamic, reversible epigenetic modification involving the addition or removal of methyl groups from lysine, arginine or glutamine residues. Aberrant activity of histone methylation writers, erases and readers has been implicated in several cancer types, including HCC. In this review, we provide an overview of research on the role of histone methylation in pre-cancerous and cancerous HCC published over the last 5 years. In particular, we present the evidence linking environmental factors such as diet, viral infections and carcinogenic agents with dysregulation of histone methylation during liver cancer progression with the aim to highlight future therapeutic possibilities (AU)
Texto completo:
Disponível
Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Lesões Pré-Cancerosas
/
Histonas
/
Carcinoma Hepatocelular
/
Neoplasias Hepáticas
Limite:
Adulto
/
Humanos
Idioma:
Inglês
Revista:
Clin. transl. oncol. (Print)
Ano de publicação:
2023
Tipo de documento:
Artigo
Instituição/País de afiliação:
University of Crete/Greece
/
University of Cyprus/Cyprus