Synchronous bilateral breast cancer treated with a 3-week hypofractionated radiotherapy schedule: clinical and dosimetric outcomes
Clin. transl. oncol. (Print)
; 23(9): 1915-1922, sept. 2021. ilus
Artigo
em Inglês
| IBECS
| ID: ibc-222190
Biblioteca responsável:
ES1.1
Localização: ES15.1 - BNCS
ABSTRACT
Background and purpose Synchronous bilateral breast cancer (SBBC) accounts for 13.5% of breast cancer patients. The aim of this study was to evaluate dosimetric issues, clinical outcomes, and acute toxicities for SBBC patients receiving synchronous bilateral hypofractionated radiotherapy (SBHRT) and to compare them with patients treated with synchronous bilateral normofractionated RT schedule (SBNRT). Materials and methods From April 2016 to March 2020, 39 SBBC patients were referred to our institution. Patients were divided according to their prescription dose Group A 50 Gy/25fx (fractions), B 6064 Gy/25fx, C 40.05 Gy/15fx; D 48 Gy/15fx. Toxicity was evaluated using Common Terminology Criteria for Adverse Events (CTCAE)v.5.0. Results 34 patients were finally evaluated. Median follow-up was 24 months for NF schedule and 9 months for HF schedule. In the HF schedule, no acute side-effects > G2 were observed and no dermatitis was reported in 6th month´s assessments. 95% of patients have no evidence of disease and only 1 patient presented local relapse in the first mammography after RT. No distant failures or deaths were observed. Regarding dosimetric issues, the inter-patient average Dmean for the heart was Group A 5.0 Gy (4.65.5), Group B 4.4 Gy (4.15.4), Group C 4.8 Gy (4.55.1) and Group D 5.3 Gy (4.45.6). For the lungs, the inter-patient average Dmean was Group A 10.8 Gy (9.812.2), Group B 11.5 Gy (11.312), Group C 9.8 Gy (9.310.5) and Group D 10.5 Gy (1011.3). Conclusions This is the first study reporting the safety, feasibility, and tolerability of 40.05 Gy/15fx over 3 weeks for the treatment of SBBC patients. Further study with larger accrual is mandatory (AU)
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Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Neoplasias da Mama
/
Hipofracionamento da Dose de Radiação
/
Neoplasias Primárias Múltiplas
Limite:
Feminino
/
Humanos
Idioma:
Inglês
Revista:
Clin. transl. oncol. (Print)
Ano de publicação:
2021
Tipo de documento:
Artigo
Instituição/País de afiliação:
Hospital Universitari Son Espases/Spain