The effect of dexmedetomidine on the post operation recovery of gastrointestinal function undergoing intestinal surgery: implications for retired athletes

ABSTRACT

Objective: To investigate the effect of dexmedetomidine on the recovery of gastrointestinal function after intestinal surgery. Methods: A total of 94 cases of gastrointestinal endoscopic surgery in our hospital from February 2020 to April 2022 were selected and randomly divided into dexmedetomidine group (group D, n=47) and control group (group C, n=47), There is no restriction on gender and age. Group E was given 1 μg/kg of dexmedetomidine before induction of anesthesia, and 0.5 μg/kg.h was pumped during the maintenance period of anesthesia. Group C was given an equal volume of normal saline. Heart rate (HR) and mean arterial pressure (MAP) were recorded at five time points before anesthesia (T0), after intubation (T1), skin incision (T2), after skin incision 1h (T3), and at the end of surgery (T4). BIS, intraoperative dosage of propofol and remifentanil, VAS score and Ramsay sedation score at 24h, 48h, 72h after operation, I-FEED scoreand bowel sound recovery time at 24h, 48h, 72h, 96h after operation, exhaust time, eating time, defecation time, and discharge time. Results: Compared with group C, the MAP and HR of group D were more stable, the consumption of anesthetics in group D was significantly lower, and the VAS score of group E was lower than that of group C at 24, 48, and 72 hours after operation (P<0.05). The I-FEED score at 24h, 48h, 72h, and 96h after operation and the incidence of PONV and POGD in group D were lower than those in group C (P＜0.05). Postoperative bowel sounds recovery time, exhaust time, eating time, defecation time and hospitalization days in group D were lower than those in group C, and the difference was statistically significant (P<0.05). Conclusion: Dexmedetomidine is applied in intestinal surgery, it can stabilize the induction period and intraoperative hemodynamics, reduce the amount intraoperative anesthetics, promote the recovery of gastrointestinal function, and accelerate the recovery of athletic patients. (AU)