Oral Kaposi sarcoma development is associated with HIV viral load, CD4+ count and CD4+/CD8+ ratio / El desarrollo del sarcoma de Kaposi oral está asociado con carga viral de VIH, recuento de CD4+ y relación CD4+/CD8+
Med. oral patol. oral cir. bucal (Internet)
; 26(6): e748-e753, Nov. 2021. tab, ilus
Artigo
em Inglês
| IBECS
| ID: ibc-224678
Biblioteca responsável:
ES1.1
Localização: ES15.1 - BNCS
ABSTRACT
Background:
Kaposis sarcoma (KS) is an uncommon, multifocal and angioproliferative lesion, which demon-strates a poor prognosis. The aim of the present research was to explore the association of HIV viral load, CD4+and CD8+ counts and the CD4+/CD8+ ratio on the risk of oral Kaposis sarcoma (KS) development.Material andMethods:
A total of 62 patients were retrieved from March 2008 to October 2020 from the files oftwo oral pathology centres. Clinical, laboratory and follow-up data were retrieved from their medical files. Poissonregression was used to explore the role of history of immunosuppression and its association with oral KS develop-ment. A P-value <0.05 was considered significant.Results:
Sixty-two patients were included in the present study (32 with oral KS and 30 with no presentation oflesions anywhere on the body). Patients with oral KS presented a mean age of 32.6 years, and male patients weremore affected. The hard palate (15 cases; 46.8%) was the main anatomical site affected. The lesions were mostlypresented as swellings (13 cases; 40.6%) and nodules (12 cases; 37.5%). Systemic manifestations were also ob-served, including candidiasis (4 cases; 12.5%), bacterial infection (3 cases; 9.3%), tuberculosis (3 cases; 9.3%),herpes simplex (3 cases; 9.3%) and pneumonia (3 cases; 9.3%). A significant correlation was observed betweenHIV viral load, CD4+ count and the CD4+/CD8+ ratio with oral KS development.Conclusions:
HIV viral load, CD4+ count and the CD4+/CD8+ ratio are associated with oral KS development.(AU)
Texto completo:
Disponível
Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Sarcoma de Kaposi
/
Linfócitos T CD4-Positivos
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Infecções por HIV
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Linfócitos T CD8-Positivos
/
Contagem de Linfócito CD4
/
Carga Viral
Limite:
Adulto
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Med. oral patol. oral cir. bucal (Internet)
Ano de publicação:
2021
Tipo de documento:
Artigo
Instituição/País de afiliação:
Instituto do Câncer do Estado de São Paulo (ICESP-FMUSP)/Brazil
/
João de Barros Barreto University Hospital (JBBUH)/Brazil
/
Piracicaba Dental School University of Campinas (UNICAMP)/Brazil
/
University of Campinas (UNICAMP)/Brazil