The crosstalk between autophagy and myeloid-derived suppressor cell responses in cancer
Clin. transl. oncol. (Print)
; 25(10): 2832-2840, oct. 2023. ilus
Artigo
em Inglês
| IBECS
| ID: ibc-225063
Biblioteca responsável:
ES1.1
Localização: ES15.1 - BNCS
ABSTRACT
The development of cancers is aided by the accumulation of myeloid-derived suppressor cells (MDSCs) within tumors, which are highly effective at suppressing anti-tumor immune responses. Direct cell-to-cell interaction and the production of immunosuppressive mediators have both been proposed as pathways for MDSC-mediated suppression of anti-tumor immune responses. The majority of current cancer treatments focus on altering the development and activity of MDSCs so that they have more of an immunogenic character. Autophagy is a catabolic system that contributes to the breakdown of damaged intracellular material and the recycling of metabolites. However, depending on the stage of tumor growth, autophagy can play both a prophylactic and a therapeutic function in carcinogenesis. However, several indirect lines of research have indicated that autophagy is a significant regulator of MDSC activity. The purpose of this work was to outline the interactions between MDSC and autophagy in cancer (AU)
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Espanha
Base de dados:
IBECS
Assunto principal:
Autofagia
/
Células Supressoras Mieloides
/
Neoplasias
Limite:
Humanos
Idioma:
Inglês
Revista:
Clin. transl. oncol. (Print)
Ano de publicação:
2023
Tipo de documento:
Artigo
Instituição/País de afiliação:
Chengdu University of Traditional Chinese Medicine/China