Predicting Positive Repeat Prostate Biopsy Outcomes: Comparison of Machine Learning Approaches to Identify Key Parameters and Optimal Algorithms
Arch. esp. urol. (Ed. impr.)
; 76(7): 494-503, 28 sept. 2023.
Artigo
em Inglês
| IBECS
| ID: ibc-226427
Biblioteca responsável:
ES1.1
Localização: ES15.1 - BNCS
ABSTRACT
Background:
Innovative strategies are necessary to enhance prostate cancer diagnosis whilst reducing unnecessary and invasive repeat biopsies. This study aimed to determine the significant parameters affecting repeat prostate biopsy outcomes and develop an optimal machine learning algorithm for predicting positive repeat prostate biopsy results.Methods:
We analysed data from 174 men who underwent repeated prostate biopsies between January 2008 and December 2022. Systematic multiple-core, ultrasound-targeted prostate biopsies were performed, each two samples from prostatic transitional zone and peripheral zone were obtained bilaterally. Clinical characteristics were collected, including patients age, initial prostate volume, prostate-specific antigen (PSA) level, free PSA (fPSA)/PSA ratio, biopsy core numbers, pathological result; The time interval between first and latest prostate biopsy; Latest PSA level, fPSA/PSA ratio, biopsy core numbers; And final pathological diagnosis. Six feature selection methods, namely, variable ranking, correlation matrix, random forest regression, recursive feature elimination, cross-validation and forward selection, were employed to identify key influencing factors for repeat biopsy outcomes. Subsequently, the performance of seven machine learning algorithms, namely, multivariable logistic regression (LR), K-nearest neighbour search (KNN), support vector classification (SVC), decision tree (DT), random forest classifier (RF), naïve Bayes classifier (NBC) and gradient booster tree (GB), was assessed based on accuracy, misclassification, recall, specificity, precision and receiver operating characteristic (ROC) area under the curve (AUC). About 70% of patients were used as the training dataset, meanwhile remaining 30% as validation dataset.Results:
52 were ultimately diagnosed with prostate cancer following the final pathological examination. The remaining 122 patients were negative (AU)
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Espanha
Base de dados:
IBECS
Assunto principal:
Neoplasias da Próstata
Limite:
Idoso
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Arch. esp. urol. (Ed. impr.)
Ano de publicação:
2023
Tipo de documento:
Artigo
Instituição/País de afiliação:
Shanghai Jiao Tong University/China
/
Tongji University School of Medicine/China
/
Tsinghua University/China