The expression of corticotropin-releasing hormone family peptides in premalignant and malignant vulvar lesions
Clin. transl. oncol. (Print)
; 26(1): 260-268, jan. 2024. tab, ilus
Article
em En
| IBECS
| ID: ibc-229164
Biblioteca responsável:
ES1.1
Localização: ES15.1 - BNCS
ABSTRACT
Objectives To examine the relation of corticotropin-releasing hormone (CRH) family peptides with inflammatory processes and oncogenesis, emphasizing in vulvar inflammatory, premalignant and malignant lesions, as well as to investigate the possibility of lesion cells immunoescaping, utilizing FAS/FAS-L complex. Methods Immunohistochemical expression of CRH, urocortin (UCN), FasL and their receptors CRHR1, CRHR2 and Fas was studied in vulvar tissue sections obtained from patients with histologically confirmed diagnosis of lichen, vulvar intraepithelial neoplasia (VIN) and vulvar squamous cell carcinoma (VSCC). The patient cohort was selected from a tertiary teaching Hospital in Greece, between 2005 and 2015. For each of the disease categories, immunohistochemical staining was evaluated and the results were statistically compared. Results A progressive increase of the cytoplasmic immunohistochemical expression of CRH and UCN, from precancerous lesions to VSCC was observed. A similar increase was detected for Fas and FasL expression. Nuclear localization of UCN was demonstrated in both premalignant and VSCC lesions, with staining being significantly intensified in carcinomas, particularly in the less differentiated tumor areas or in the areas at invasive tumor front. Conclusions Stress response system and CRH family peptides seem to have a role in inflammation maintenance and progression of vulvar premalignant lesions to malignancy. It seems that stress peptides may locally modulate the stroma through Fas/FasL upregulation, possibly contributing to vulvar cancer development (AU)
Palavras-chave
Texto completo:
1
Coleções:
06-national
/
ES
Base de dados:
IBECS
Assunto principal:
Lesões Pré-Cancerosas
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Neoplasias Vulvares
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Hormônio Liberador da Corticotropina
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Carcinoma de Células Escamosas
Limite:
Female
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Humans
Idioma:
En
Revista:
Clin. transl. oncol. (Print)
Ano de publicação:
2024
Tipo de documento:
Article