Effects of antipsychotics on amino acid levels in patients with first-episode schizophrenia: A prospective study
Eur. j. psychiatry
; 38(2): [100229], Apr.-Jun. 2024.
Artigo
em Inglês
| IBECS
| ID: ibc-231864
Biblioteca responsável:
ES1.1
Localização: ES15.1 - BNCS
ABSTRACT
Background and objectives Alterations in the molecular mechanisms of specific amino acids (AAs) may be implicated in the pathophysiology of schizophrenia (SZ). However, little is known about antipsychotic drugs influence on levels of AAs. This study aimed to further explore antipsychotics' effects on AAs and serum lipid levels in first-episode SZ. Methods Eighty subjects with the International Classification of Diseases, Tenth Edition (ICD-10) criteria-defined SZ were enrolled. The levels of 31 AAs were measured in plasma samples using ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). Results Ten AAs (i.e., citrulline, sarcosine, tyrosine, leucine, proline, hydroxyproline, kynurenine, tryptophan, valine and isoleucine) were observed to be higher and three AAs (i.e., GABA, aminobutyric acid and asparaginic acid) were lower in 80 patients with first-episode SZ after various antipsychotics treatment. In addition, there were 1 out of 31 AAs altered after olanzapine treatment and there were only 2 out of 31 AAs altered after risperidone treatment. Furthermore, serum triglyceride (TG) was markedly upregulated after olanzapine treatment, while Apolipoprotein A1 (ApoA1) was generally upregulated after risperidone treatment in patients with first-episode SZ. Conclusions Taken together, antipsychotic treatment can affect the plasma levels of AAs in patients with first-episode SZ, and olanzapine and risperidone have differential effects on the levels of AAs. (AU)
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Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Esquizofrenia
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Antipsicóticos
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Aminoácidos
Limite:
Adolescente
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Adulto
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Idoso
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Feminino
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Humanos
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Masculino
Idioma:
Inglês
Revista:
Eur. j. psychiatry
Ano de publicação:
2024
Tipo de documento:
Artigo
Instituição/País de afiliação:
Huai'an Third People's Hospital/China
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Huai'an Third People's Hospital/China