Effect of inhaled fluticasone on lung function in infants with recurrent wheezing: a randomised controlled trial
Allergol. immunopatol
; 37(2): 57-62, mar.-abr. 2009. tab, graf
Artigo
em Inglês
| IBECS
| ID: ibc-61484
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
Background:
Inhaled corticosteroids are used to treat infants with trouble some asthma-like symptoms but their effect on the lung function of these young patients is controversial. Material andMethods:
Forty-four infants with recurrent wheezing (more than 3 episodes) and family history of asthma completed this randomised, parallel, double-blind, controlled trial to compare the effect on lung function (main end point) of once-daily inhaled fluticasone (375g) versus placebo for 3 months. Pulmonary function was measured while infants were asymptomatic, using the raised volume rapid thoracic compression technique (spirometry-like), and values were converted to z-scores.Results:
The fluticasone group showed a significant increase in forced flows, (p < 0.001), a lower number of physician diagnosed wheezing episodes (p < 0.002), and a significant decrease in the parent-reported number of wheezing episodes per month (p < 0.03), as compared to placebo. One third of parents in the placebo group reported a clinical improvement in their infants.There was no significant difference in morning plasma cortisol between groups at entry or discharge.Conclusions:
We conclude that once-daily treatment with 375g fluticasone increased forced flows and controlled symptoms in infants with recurrent wheezing without altering plasma cortisol levels. The spirometry-like technique is a useful tool to objectively assess the efficacy of anti-asthma medications in infants with repeated trouble some asthma-like symptoms (AU)RESUMEN
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Coleções:
Bases de dados nacionais
/
Espanha
Contexto em Saúde:
ODS3 - Saúde e Bem-Estar
Problema de saúde:
Meta 3.4: Reduzir as mortes prematuras devido doenças não transmissíveis
Base de dados:
IBECS
Assunto principal:
Asma
/
Corticosteroides
/
Antiasmáticos
Tipo de estudo:
Ensaio clínico controlado
Limite:
Criança
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Allergol. immunopatol
Ano de publicação:
2009
Tipo de documento:
Artigo
Instituição/País de afiliação:
Hospital El Pino/Chile
/
James Whitcomb Riley Hospital for Children/USA