Protective effect of 17Beta-estradiol on oxidative stress and liver dysfunction in aged male rats
J. physiol. biochem
; 63(3): 195-202, jul.-sept. 2007. ilus, tab
Artigo
em En
| IBECS
| ID: ibc-72012
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ES15.1
Localização: ES15.1 - BNCS
ABSTRACT
In aging liver oxidative stress increases due to the decrease in antioxidant bio-moleculessuch as estrogens which can be modified by hormonal replacement therapy(HRT). With this in mind, we hypothesized that age-related decline in steroidogenesismay be associated with the impairment of the antioxidant defense cells in liver,the increase in lipid peroxidation, hepatic dysfunction and histological changes;estrogens prevent all these changes induced by aging. 17â-estradiol treatment wasinitiated in 12 month-old Wistar rats, and continued until 18 months of age. Ourresults showed that 17Beta-estradiol (E2) level in the serum of the aged untreated ratswas reduced by 32% in 18 month-old rats compared to the young animals (4-month-old). The superoxide dismutase (SOD), catalase (CAT), and gluthatione peroxidase(GPX) activities were reduced by 47, 46, and 29% respectively in old ratliver. In addition, the TBARs in liver and hepatic dysfunction parameters in plasmasuch as gamma-glutamyl transferase (GGT), phosphatase alkalin (PAL) as well asbilirubin level increased significantly in old rats, and histological changes were investigated.In E2-treated rats, protective effects were observed. Indeed, 17Beta-estradiolattenuates all changes induced by aging. The 17Beta-estradiol level was higher in old E2-treated rats compared to the control rats. Moreover, the SOD, CAT and GPX activitieswere higher by +28, +15, and +11% respectively. This anti-aging effect of estrogenswas clarified by a lower level of lipid peroxidation and liver dysfunction parametersas well as by histological observation (AU)
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Espanha
Base de dados:
IBECS
Assunto principal:
Catalase
/
Peroxidase
/
Estresse Oxidativo
/
Estradiol
/
Fígado
Limite:
Animais
Idioma:
Inglês
Revista:
J. physiol. biochem
Ano de publicação:
2007
Tipo de documento:
Artigo
Instituição/País de afiliação:
CHU H. Bourguiba/Tunisia
/
Faculty of Sciences/Tunisia
/
University of Caen/France