Development of Gastro Retentive Drug Delivery System of Cephalexin by using Factorial Design
Ars pharm
; 50(1): 8-24, ene.-mar. 2009. tab, graf, ilus
Artigo
em Inglês
| IBECS
| ID: ibc-75341
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
The objective of this research work was to formulate and optimize the floating drug delivery system containing cephalexin using 23 factorial design. Floating tablets were prepared by direct compression method incorporating HPMC K4M, xanthan gum, guar gum, sodium bicarbonate and tartaric acid as gas generating agent. The influence of independent variables like, polymer polymer ratio, polymer type and tartaric acid on floating lag time and cephalexin release profile were studied. The diffusion exponent (n) of Krosmeyer Peppas for optimized formulation was found to be 0.635 which indicates the mechanism of drug release was anomalous transport. Floating lag time of optimized formulation was 1.50 min and remained buoyant for 24 hrs. Optimized formulation was checked for stability at 40ºC / 75% RH which was found to be stable. Scanning electron microscopy study revealed gel formation. FT-IR studies revealed that there was no chemical interaction between cephalexin and other excipients(AU)
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Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Microscopia Eletrônica de Varredura
/
Cefalexina
/
Sistemas de Liberação de Medicamentos
/
Espectroscopia de Infravermelho com Transformada de Fourier
/
Trato Gastrointestinal
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Ars pharm
Ano de publicação:
2009
Tipo de documento:
Artigo
Instituição/País de afiliação:
Acharya and B.M Reddy college of pharmacy/India
/
Visveswarapura Institute of Pharmaceutical Sciences/India