Expanding role for the apelin/APJ systemin physiopathology
J. physiol. biochem
; 63(4): 359-374, oct.-dic. 2007. ilus, graf
Artigo
em Inglês
| IBECS
| ID: ibc-76690
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
Apelin is a bioactive peptide known as the ligand of the G protein-coupled receptorAPJ. Diverse active apelin peptides exist under the form of 13, 17 or 36 aminoacids, originated from a common 77-amino-acid precursor. Both apelin and APJmRNA are widely expressed in several rodent and human tissues and have functionaleffects in both the central nervous system and peripheral tissues. Apelin has beenshown to be involved in the regulation of cardiovascular functions, fluid homeostasis,vessel formation and cell proliferation. More recently, apelin has been describedas an adipocyte-secreted factor (adipokine), up-regulated in obesity. By acting as circulatinghormone or paracrine factor, adipokines are involved in physiological regulations(fat depot development, energy storage, metabolism or eating behavior) or inthe promotion of obesity-associated disorders (type 2 diabetes and cardiovasculardysfunctions). In this regard, expression of apelin gene in adipose tissue is increasedby insulin and TNFá. This review will consider the main roles of apelin in physiopathologywith particular attention on its role in energy balance regulation and inobesity-associated disorders (AU)
RESUMEN
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Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Peptídeos e Proteínas de Sinalização Intercelular
/
Receptores Acoplados a Proteínas G
Tipo de estudo:
Estudo de etiologia
Limite:
Animais
/
Humanos
Idioma:
Inglês
Revista:
J. physiol. biochem
Ano de publicação:
2007
Tipo de documento:
Artigo
Instituição/País de afiliação:
INSERM/France
/
University of Navarra/Spain
/
University of País Vasco/Spain
/
Université Toulouse III Paul-Sabatier/France