Predictive baseline criteria of primary therapeutic failure in chronic hepatitis C genotype 1
Rev. esp. enferm. dig
; 102(4): 234-238, abr. 2010. tab
Artigo
em Inglês
| IBECS
| ID: ibc-79727
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
Background and aims:
more than half of patients with genotype 1 chronic hepatitis C (CHC) do not achieve a sustained viral response (SVR) to current antiviral therapy due to primary non-response, relapse or intolerance. Factors related to each of these unfavorable outcomes are different and the last two may be partially prevented. Our aim was to identify basal criteria to predict the risk of primary failure. Patients andmethods:
we included 251 consecutive patients (152 males) from a single centre, infected with HCV genotype 1 and not previously treated. SVR was achieved in 141 patients and primary failure in 110.Results:
high vs. low viral load (> 400,000 IU/mL, OR = 6.17; 95% CI 2.50-15.23), high serum GGT (> 60 IU/mL, OR = 4.25; 95% CI 2.49-7.24), low serum cholesterol (< 178 mg/dL, OR = 2.93; 95% CI 1.75-4.92) and older age (> 47 yrs., OR = 1.79; 95% CI 1.08-2.96) were associated to the risk of primary failure in the lineal logistic regression analysis. From the 58 patients carrying all the first three negative criteria, 46 (79.3%) were primary non-responders.Conclusions:
the negative basal profile identified in this study is based on easily available data and provides information about the risk of primary therapeutic failure, and may help to decide whether antiviral therapy should be offered to a single patient(AU)
Texto completo:
Disponível
Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Antivirais
/
Hepatite C Crônica
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
Limite:
Humanos
Idioma:
Inglês
Revista:
Rev. esp. enferm. dig
Ano de publicação:
2010
Tipo de documento:
Artigo
Instituição/País de afiliação:
Universidad Complutense de Madrid/Spain