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Evaluation of cell proliferation rate in non-dysplastic leukoplakias
Campos Hildebrand, Laura-de; Carrard, Vinicius-Coelho; Silva Lauxen, Isabel-da; Quadros, Onofre-Francisco de; Chaves, Anna-Cecília-Moraes; ant’Ana-Filho, Manoel S.
Afiliação
  • Campos Hildebrand, Laura-de; Universidade Federal do Rio Grande do Sul. School of Dentistry. RS. Brazil
  • Carrard, Vinicius-Coelho; Universidade Federal do Rio Grande do Sul. School of Dentistry. RS. Brazil
  • Silva Lauxen, Isabel-da; Universidade Federal do Rio Grande do Sul. School of Dentistry. RS. Brazil
  • Quadros, Onofre-Francisco de; Universidade Federal do Rio Grande do Sul. School of Dentistry. RS. Brazil
  • Chaves, Anna-Cecília-Moraes; Universidade Federal do Rio Grande do Sul. School of Dentistry. RS. Brazil
  • ant’Ana-Filho, Manoel S; Universidade Federal do Rio Grande do Sul. School of Dentistry. RS. Brazil
Med. oral patol. oral cir. bucal (Internet) ; 15(2): 328-334, mar. 2010. ilus, tab
Article em En | IBECS | ID: ibc-80236
Biblioteca responsável: ES1.1
Localização: BNCS
ABSTRACT
Objective: Analyze whether the most frequent cases of non-dysplastic leukoplakias, hyperkeratosis (H), acanthosis(A), and hyperkeratosis with acanthosis (HA) have similar cell proliferation rates and to compare them withepithelial dysplastic (ED) leukoplakias and normal oral epithelium (NOE).Study design: The sample comprised10 cases of normal oral epithelium, 10 cases of hyperkeratosis, 10 cases of acanthosis, 10 cases of hyperkeratosiswith acanthosis and 10 cases of epithelial dysplasia. The mean number of AgNORs per nucleus (mAgNOR) andthe mean percentage of cells with 1, 2, 3 and 4 or more AgNORs per nucleus (pAgNOR) were recorded. Results:The results of mAgNOR showed differences between disorders in the evaluation of the basal layer, of the parabasallayer, and in the overall evaluation. mAgNOR and pAgNOR=2 increased progressively from normal oralepithelium to hyperkeratosis with acanthosis, hyperkeratosis, acanthosis and epithelial dysplasia (p<0.05). Cellproliferation rate was different between different subtypes of non-dysplastic leukoplakias and this group presenteda higher proliferative behavior when compared to normal oral epithelium. Conclusion: It may be suggested thatnon-dysplastic leukoplakias had different characteristics regarding cell proliferation rates and sometimes showeda proliferative behavior similar to that found in epithelial dysplasia. More studies should be conduced to increaseknowledge about the biological profile of non-dysplastic leukoplakias, especially as it pertains to acanthosis (AU)
Assuntos
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Coleções: 06-national / ES Base de dados: IBECS Assunto principal: Leucoplasia Oral / Proliferação de Células Limite: Female / Humans / Male Idioma: En Revista: Med. oral patol. oral cir. bucal (Internet) Ano de publicação: 2010 Tipo de documento: Article
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Coleções: 06-national / ES Base de dados: IBECS Assunto principal: Leucoplasia Oral / Proliferação de Células Limite: Female / Humans / Male Idioma: En Revista: Med. oral patol. oral cir. bucal (Internet) Ano de publicação: 2010 Tipo de documento: Article