Salivary and serum levels of substance P, neurokinin A and calcitonin generelated peptide in burning mouth syndrome

ABSTRACT

Background: Burning mouth syndrome (BMS) is an enigmatic condition with the etiopathogenesis remaininglargely obscure. However, a neuropathic basis for BMS continues to be an area of active clinical and researchinterest.Aim: It is becoming increasingly evident that certain oral disorders may be modulated by imbalances in certainneuropeptides such as substance P (SP), neurokinin A (NKA) and calcitonin gene-related peptide (CGRP) thereforewe measured SP, NKA and CGRP in the saliva and sera of BMS patients as well as controls.Subjects and Methods: Salivary and serum SP, NKA and CGRP were determined in the 26 female patients withburning mouth syndrome (age range 51-78, mean 65.69 yrs), and in the 22 female controls (age range 24-82, mean49.72 yrs). Serum and salivary SP, NKA, CGRP levels were determined by commercial competitive enzyme immunoassaykits. Statistical analysis was performed by use of descriptive statistics and analysis of variance.Results and Conclusions: No significant differences in salivary SP, NKA and CGRP as well as serum SP andCGRP between BMS patients and controls could be found. However, significantly decreased serum neurokinin A(p<0.05) in BMS patients may reflect an inefficient dopaminergic system (AU)

RESUMEN

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