Valoración de la función tiroidea durante la gestación: intervalos de referencia de tirotropina y tiroxina no unida a proteína durante el primer trimestre / Evaluation of testosterone levels through distinct analytic methods in healthy men
Endocrinol. nutr. (Ed. impr.)
; 57(7): 290-295, ago.-sept. 2010. tab
Artigo
em Espanhol
| IBECS
| ID: ibc-87547
Biblioteca responsável:
ES1.1
Localização: BNCS
RESUMEN
Objetivos Estudiar los rangos de normalidad de testosterona en varones jóvenes sanos y comparar los resultados de los distintos métodos analíticos utilizados. Material y métodos Se incluyeron 20 hombres sanos con una edad media de 24,5 años (desviación estándar (DE) 5,04), un índice de masa corporal (IMC) medio de 23,8% (DE 3,3). Se determinaron las concentraciones de testosterona total (TT) mediante inmunoquimioluminiscencia (ICLA), de testosterona libre (TL) mediante radioinmunoensayo (RIA), y se calculó la testosterona libre calculada (TLc) y la testosterona biodisponible (TB) mediante la fórmula de Vermeulen. Se midieron las concentraciones séricas de lutropina (LH), folitropina (FSH) y proteína ligadora de hormonas sexuales (SHBG) por método inmunorradiométrico (IRMA).Resultados Las concentraciones medias de TT fueron de 20nmol/l (DE 4,96), las de TL de 0,054nmol/l (DE 0,01), los de TLc de 0,3834nmol/l (DE 0,09) y los de TB de 9,9nmol/l (DE 2,8 ). No se encontró correlación entre las concentraciones de testosterona medidos por los distintos métodos, excepto entre TL y TLc (r=0,662; p<0,003) y entre TLc y TB (r=0,979; p<0,0001). Existe una asociación inversa entre IMC y las concentraciones de testosterona total (r −0,52; p<0,017).Conclusiones Es necesario establecer el intervalo de normalidad para la testosterona en hombres jóvenes sanos en función del método analítico utilizado (AU)
ABSTRACT
Plasma testosterone concentrations are essential for the diagnosis of several causes of hypogonadism, including late-onset hypogonadism. Defining the normal range for testosterone concentrations poses certain difficulties due to the changes that occur with age and the variability of the different analytical methods used. Objectives To study normal ranges of testosterone in healthy young men and to compare the results of distinct analytical methods. Material and methods We recruited 20 healthy men with a mean age of 24.5 years (standard deviation (SD) 5.04) and a mean body mass index (BMI) of 23.8% (SD 3.3). Total testosterone (TT) was measured by immunochemiluminescence (ICLA) and free testosterone (FT) by radioimmunoassay (RIA). Calculated free testosterone (FTc) and bioavailable testosterone (BT) were calculated using Vermeulen's formula. Serum lutropin (LH), follitropin (FSH) and sex hormone binding globulin (SHBG) were measured by immunoradiometric assays (IRMA).Results The mean concentrations were 20nmol/l (SD 4.96) for TT, 0.054nmol/L (SD 0.01) for FT, 0.3834nmol/L (SD 0.09) for FTc and 9.9nmol/L (SD 2.8) for BT. There was no correlation between testosterone measured by different methods other than an association between FT and FTc (r=0.662, p<0.003) and between FTc and BT (r=0.979, p<0.0001). An inverse correlation was found between BMI and TT concentrations (r −0.52, p<0.017).Conclusions The normal range for testosterone in healthy young men should be established in each laboratory based on the analytical method used (AU)
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Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Complicações na Gravidez
/
Doenças da Glândula Tireoide
/
Tiroxina
/
Tireotropina
Limite:
Feminino
/
Humanos
/
Gravidez
Idioma:
Espanhol
Revista:
Endocrinol. nutr. (Ed. impr.)
Ano de publicação:
2010
Tipo de documento:
Artigo
Instituição/País de afiliação:
Hospital Naval Cartagena/España
/
Hospital Universitario Santa María del Rosell/España