Salivary and serum interleukin 1 beta, interleukin 6 and tumor necrosis factor alpha in patients with leukoplakia and oral cancer
Med. oral patol. oral cir. bucal (Internet)
; 17(1): 10-15, ene. 2012. tab
Artigo
em Inglês
| IBECS
| ID: ibc-98910
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
Objectives:
The aim of study was to compare salivary and serum concentrations of interleukin 1 beta (IL-1Beta), interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-Alpha) in patients with oral leukoplakia, oral cancer and healthy controls. Studydesign:
Eighty eight patients (28 with oral cancer, 29 leukoplakia, and 31 healthy controls) were included in this study. Cytokine concentrations were measured by commercial enzyme linked immunoassay.Results:
Salivary IL-1Beta and IL-6 were significantly higher in oral cancer patients than in patients with leukoplakia and control group (p<0.05). No differences in concentrations of salivary TNF-Alpha between either of the groups were observed. Serum concentrations of IL-1Beta were below level of detection in all but two participants. No significant differences between the groups were observed in serum concentrations of IL-6. Serum TNF-Alpha was significantly higher in control subjects than in oral cancer patients.Conclusions:
Patients with oral cancer have elevated levels of inflammatory cytokines in their saliva. Whether this elevation can be used for monitoring the malignant transformation of oral leukoplakia remains to be answered by further follow up studies (AU)
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Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Leucoplasia Oral
/
Neoplasias Bucais
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
Limite:
Humanos
Idioma:
Inglês
Revista:
Med. oral patol. oral cir. bucal (Internet)
Ano de publicação:
2012
Tipo de documento:
Artigo
Instituição/País de afiliação:
Clinical Hospital Dubrava/s. p
/
Clinical hospital "Sestre milosrdnice"/s. p
/
Croatian Institute for Transfusion Medicine/s. p
/
University of Split/s. p
/
University of Zagreb/s. p