Double-application of platelet-rich plasma on bone healing in rabbits
Med. oral patol. oral cir. bucal (Internet)
; 17(1): 171-177, ene. 2012. ilus
Article
em En
| IBECS
| ID: ibc-98936
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
Objective: Platelet-rich plasma (PRP) is considered to enhance bone formation especially at early stages of wound healing, depending on the limited and short life-span of platelets and growth factors. The aim of this study was to evaluate efficacy of double-application of PRP (DA-PRP) on bone healing in a rabbit calvarial defect model. Study design: Twenty-eight rabbits, each had two surgically prepared calvarial bone defects (10mm diameter),were included in this study and randomly divided into six groups. Defects (n=56) were treated with single-application of PRP (SA-PRP)(n=10), SA-PRP and beta-tricalciumphosphate (SA-PRP+TCP)(n=10), DA-PRP (n=8),DA-PRP and beta-tricalcium phosphate (DA-PRP+TCP)(n=8), beta-tricalcium phosphate (TCP)(n=10) or left empty(Control)(n=10). Animals were sacrificed at 30 days postoperatively. Results: The new bone (NB%) and defect fill (DF%) percentages were calculated from histological slides by image-analyzer software and statistically analysed. All test groups showed higher NB% than control, but differences among all groups were insignificant. The TCP treated groups had significantly higher DF% than groups treated without TCP, however the DF% differences between control, SA-PRP and DA-PRP or TCP, SA-PRP+TC Por DA-PRP+TCP were insignificant. Conclusion: Although new bone formation was histomorphologically remarkable at double-application PRP groups, statistical analyses of the histomorphometric data revealed no significant difference (AU)
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Coleções:
06-national
/
ES
Base de dados:
IBECS
Assunto principal:
Osteogênese
/
Osso e Ossos
/
Regeneração Óssea
/
Plasma Rico em Plaquetas
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Med. oral patol. oral cir. bucal (Internet)
Ano de publicação:
2012
Tipo de documento:
Article