The role of mast cells on angiogenesis in oral squamous cell carcinoma
Med. oral patol. oral cir. bucal (Internet)
; 17(2): 190-196, mar. 2012. ilus, tab
Artigo
em Inglês
| IBECS
| ID: ibc-98939
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
Objective:
Angiogenesis or neovascularization has long been known to aid in progression and metastasis of malignant tumors. Tumor angiogenesis is a complex event mediated by angiogenic factors released from cancer cells and or by host immune cells. Mast cells may induce tumor progression and potentiate metastasis by stimulating angiogenesis. The purpose of the present study was to validate topographic distribution of micro vessel density(MVD) and mast cell density (MCD) and help to elucidate the possible role of mast cells in tumor angiogenesis and correlating this with advanced disease parameters. StudyDesign:
MVD and MCD were investigated in tumor specimens from 30 patients diagnosed with different histologic grades of oral squamous cell carcinoma (OSCC). Intratumor vessels were stained with collagen Type IV antibody and mast cells with Toluidine blue before being measured by light microscopy.Results:
There was a significant correlation between MVD and disease progression and number of blood vessels increased from well to poorly differentiated OSCC where as MCD decreased.Conclusions:
These findings suggest that angiogenesis indeed occur in OSCC and might be used as an index to inflect the aggression of the disease however mast cells make up only a part of complex process of angiogenesis along with other factors secreted by tumor (AU)
Buscar no Google
Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Carcinoma de Células Escamosas
/
Mastócitos
/
Neovascularização Patológica
Limite:
Humanos
Idioma:
Inglês
Revista:
Med. oral patol. oral cir. bucal (Internet)
Ano de publicação:
2012
Tipo de documento:
Artigo
Instituição/País de afiliação:
G B Pant Hospital/India
/
Jaipur Dental College/Indi
/
Jaipur Dental College/India
/
Manipal College of Dental Sciences/India
/
SGT Dental College/India